Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradab...

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Main Authors: Siriporn Taokaew, Worasak Kaewkong, Worawut Kriangkrai
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Gels
Subjects:
Online Access:https://www.mdpi.com/2310-2861/9/4/277
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author Siriporn Taokaew
Worasak Kaewkong
Worawut Kriangkrai
author_facet Siriporn Taokaew
Worasak Kaewkong
Worawut Kriangkrai
author_sort Siriporn Taokaew
collection DOAJ
description Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.
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spelling doaj.art-9d22d3940c834ad08f7cd7ced0c4cc0a2023-11-17T19:21:10ZengMDPI AGGels2310-28612023-03-019427710.3390/gels9040277Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical ApplicationsSiriporn Taokaew0Worasak Kaewkong1Worawut Kriangkrai2Department of Materials Science and Bioengineering, School of Engineering, Nagaoka University of Technology, Nagaoka 940-2188, JapanDepartment of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, ThailandChitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.https://www.mdpi.com/2310-2861/9/4/277chitosanmultifunctional hydrogelsfabricationbiomedical applicationscontrolled drug delivery
spellingShingle Siriporn Taokaew
Worasak Kaewkong
Worawut Kriangkrai
Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications
Gels
chitosan
multifunctional hydrogels
fabrication
biomedical applications
controlled drug delivery
title Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications
title_full Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications
title_fullStr Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications
title_full_unstemmed Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications
title_short Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications
title_sort recent development of functional chitosan based hydrogels for pharmaceutical and biomedical applications
topic chitosan
multifunctional hydrogels
fabrication
biomedical applications
controlled drug delivery
url https://www.mdpi.com/2310-2861/9/4/277
work_keys_str_mv AT siriporntaokaew recentdevelopmentoffunctionalchitosanbasedhydrogelsforpharmaceuticalandbiomedicalapplications
AT worasakkaewkong recentdevelopmentoffunctionalchitosanbasedhydrogelsforpharmaceuticalandbiomedicalapplications
AT worawutkriangkrai recentdevelopmentoffunctionalchitosanbasedhydrogelsforpharmaceuticalandbiomedicalapplications