Mechanisms of Mitotic Kinase Regulation: A Structural Perspective
Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones. Yet each...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcell.2018.00006/full |
| _version_ | 1819209310891147264 |
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| author | Julie P. I. Welburn A. Arockia Jeyaprakash |
| author_facet | Julie P. I. Welburn A. Arockia Jeyaprakash |
| author_sort | Julie P. I. Welburn |
| collection | DOAJ |
| description | Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones. Yet each kinase has unique structural features that allow their distinct substrate recognition and modes of regulation. These unique regulatory features determine their accurate spatio-temporal activation critical for correct progression through mitosis and are exploited for therapeutic purposes. In this review, we will discuss the principles of mitotic kinase activation and the structural determinants that underlie functional specificity. |
| first_indexed | 2024-12-23T05:53:15Z |
| format | Article |
| id | doaj.art-9d2336d823114ff0aed99f419f88cbb6 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-23T05:53:15Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9d2336d823114ff0aed99f419f88cbb62022-12-21T17:57:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-02-01610.3389/fcell.2018.00006326532Mechanisms of Mitotic Kinase Regulation: A Structural PerspectiveJulie P. I. WelburnA. Arockia JeyaprakashProtein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones. Yet each kinase has unique structural features that allow their distinct substrate recognition and modes of regulation. These unique regulatory features determine their accurate spatio-temporal activation critical for correct progression through mitosis and are exploited for therapeutic purposes. In this review, we will discuss the principles of mitotic kinase activation and the structural determinants that underlie functional specificity.http://journal.frontiersin.org/article/10.3389/fcell.2018.00006/fullmitotic kinasemitosisphosphorylationstructuremechanismsubstrate |
| spellingShingle | Julie P. I. Welburn A. Arockia Jeyaprakash Mechanisms of Mitotic Kinase Regulation: A Structural Perspective Frontiers in Cell and Developmental Biology mitotic kinase mitosis phosphorylation structure mechanism substrate |
| title | Mechanisms of Mitotic Kinase Regulation: A Structural Perspective |
| title_full | Mechanisms of Mitotic Kinase Regulation: A Structural Perspective |
| title_fullStr | Mechanisms of Mitotic Kinase Regulation: A Structural Perspective |
| title_full_unstemmed | Mechanisms of Mitotic Kinase Regulation: A Structural Perspective |
| title_short | Mechanisms of Mitotic Kinase Regulation: A Structural Perspective |
| title_sort | mechanisms of mitotic kinase regulation a structural perspective |
| topic | mitotic kinase mitosis phosphorylation structure mechanism substrate |
| url | http://journal.frontiersin.org/article/10.3389/fcell.2018.00006/full |
| work_keys_str_mv | AT juliepiwelburn mechanismsofmitotickinaseregulationastructuralperspective AT aarockiajeyaprakash mechanismsofmitotickinaseregulationastructuralperspective |