Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the proteolytic activity of MALT1 and is frequently used to...

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Bibliographic Details
Main Authors: Laura Meloni, Lynn Verstrepen, Marja Kreike, Jens Staal, Yasmine Driege, Inna S. Afonina, Rudi Beyaert
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
osteoclastogenesis
mepazine
MALT1
RANK
NF-κB
phenothiazine
paracaspase
osteoclast
Online Access:https://www.mdpi.com/1420-3049/23/12/3144

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