Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation
Highlights: • A genetic variable has been identified as an atrial fibrillation risk factor. • Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect. Abstract: Atrial fibrillation (AF) is a highly prevalent arr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2023-03-01
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| Series: | Folia Medica Indonesiana |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/FMI/article/view/37126 |
| _version_ | 1797849319862173696 |
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| author | Rendra Mahardhika Putra Budi Bakti Dharmadjati Budi Susetyo Pikir Irma Maghfirah Ilma Alfia Isaridha Jannatin Nisa Arnindita |
| author_facet | Rendra Mahardhika Putra Budi Bakti Dharmadjati Budi Susetyo Pikir Irma Maghfirah Ilma Alfia Isaridha Jannatin Nisa Arnindita |
| author_sort | Rendra Mahardhika Putra |
| collection | DOAJ |
| description | Highlights:
• A genetic variable has been identified as an atrial fibrillation risk factor.
• Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect.
Abstract:
Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk. |
| first_indexed | 2024-04-09T18:41:58Z |
| format | Article |
| id | doaj.art-9d24fe1372b04dcca0aed38557dbc726 |
| institution | Directory Open Access Journal |
| issn | 2355-8393 2599-056X |
| language | English |
| last_indexed | 2024-04-09T18:41:58Z |
| publishDate | 2023-03-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Folia Medica Indonesiana |
| spelling | doaj.art-9d24fe1372b04dcca0aed38557dbc7262023-04-11T02:41:58ZengUniversitas AirlanggaFolia Medica Indonesiana2355-83932599-056X2023-03-01591859110.20473/fmi.v59i1.3712635194Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial FibrillationRendra Mahardhika Putra0https://orcid.org/0000-0001-8126-7433Budi Bakti Dharmadjati1https://orcid.org/0000-0002-9898-4970Budi Susetyo Pikir2https://orcid.org/0000-0003-0705-9462Irma Maghfirah3https://orcid.org/0000-0002-4170-216XIlma Alfia Isaridha4Jannatin Nisa Arnindita5https://orcid.org/0000-0002-3103-6239Faculty of Medicine, Universitas Airlangga; Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; Indonesian Society of Interventional CardiologyFaculty of Medicine, Universitas Airlangga; Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital,Surabaya, IndonesiaFaculty of Medicine, Universitas Airlangga; Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaFaculty of Medicine, Universitas Airlangga; Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaFaculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaHighlights: • A genetic variable has been identified as an atrial fibrillation risk factor. • Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect. Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.https://e-journal.unair.ac.id/FMI/article/view/37126atrial fibrillationpituitary homeobox 2 (pitx2) gene chromosome 4q25single-nucleotide polymorphisms (snps) cardiovascular diseases |
| spellingShingle | Rendra Mahardhika Putra Budi Bakti Dharmadjati Budi Susetyo Pikir Irma Maghfirah Ilma Alfia Isaridha Jannatin Nisa Arnindita Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation Folia Medica Indonesiana atrial fibrillation pituitary homeobox 2 (pitx2) gene chromosome 4q25 single-nucleotide polymorphisms (snps) cardiovascular diseases |
| title | Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation |
| title_full | Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation |
| title_fullStr | Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation |
| title_full_unstemmed | Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation |
| title_short | Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation |
| title_sort | five single nucleotide polymorphisms in the pitx2 gene as risk factors for atrial fibrillation |
| topic | atrial fibrillation pituitary homeobox 2 (pitx2) gene chromosome 4q25 single-nucleotide polymorphisms (snps) cardiovascular diseases |
| url | https://e-journal.unair.ac.id/FMI/article/view/37126 |
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