| Summary: | Delita Prihatni,1 Frany Charisma Budianto,1 Basti Andriyoko,1 Suryarini Trisa2 1Clinical Pathology Department, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 2Depati Hamzah Hospital, Bangka Belitung, IndonesiaCorrespondence: Delita Prihatni, Hasan Sadikin Hospital, Jln. Pasteur No. 38, Bandung, West Java, Indonesia, Tel +628122314089, Email delita.prihatni@unpad.ac.idIntroduction: sP-selectin is a glycoprotein located in α granules of platelet and endothelial’s Weibel Palade body, as expression to platelet activation and endothelial cell stimulation by SARS-CoV-2 binding with ACE2 receptor. Consumptive thrombocytopenia is also related to platelet activation. Elevation of sP-selectin and thrombocytopenia are related to COVID-19 complication and often correlated with severity of COVID-19.Purpose: Assess the correlation between sP-selectin and platelet in COVID-19 patients at intensive care and non-intensive care.Patients and Methods: The study population was hospitalized COVID-19 patients confirmed by Real-Time PCR that underwent platelet examination within 48 hours upon admission, divided into intensive care and non-intensive care group. sP-selectin examination using ELISA methods. Platelet cell count and sP-selectin divided based on normal reference range.Results: The subjects consist of 24 were in intensive care, 25 were in non-intensive care group. A 66.7% of subject in intensive care group has an elevation in sP-selection (> 44.0 ng/mL). Thrombocytopenia was significantly correlated with intensive group (r =− 0.32, p< 0.05). The combination of platelet count < 150.000/mm3 and sP-selectin > 44.0ng/mL was not correlated with the intensive and non-intensive group. Platelet and sP-selectin were not correlated with each other.Conclusion: Thrombocytopenia is able to induce the expression of sP-selectin.Keywords: COVID-19, sP-selectin, platelet, thrombocytopenia
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