The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia
Delita Prihatni,1 Frany Charisma Budianto,1 Basti Andriyoko,1 Suryarini Trisa2 1Clinical Pathology Department, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 2Depati Hamzah Hospital, Bangka Belitung, IndonesiaCorrespondence: Delita Prihatni, Hasan S...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Journal of Blood Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-correlation-between-sp-selectin-and-platelet-count-in-covid-19-pat-peer-reviewed-fulltext-article-JBM |
| _version_ | 1797646932329365504 |
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| author | Prihatni D Budianto FC Andriyoko B Trisa S |
| author_facet | Prihatni D Budianto FC Andriyoko B Trisa S |
| author_sort | Prihatni D |
| collection | DOAJ |
| description | Delita Prihatni,1 Frany Charisma Budianto,1 Basti Andriyoko,1 Suryarini Trisa2 1Clinical Pathology Department, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 2Depati Hamzah Hospital, Bangka Belitung, IndonesiaCorrespondence: Delita Prihatni, Hasan Sadikin Hospital, Jln. Pasteur No. 38, Bandung, West Java, Indonesia, Tel +628122314089, Email delita.prihatni@unpad.ac.idIntroduction: sP-selectin is a glycoprotein located in α granules of platelet and endothelial’s Weibel Palade body, as expression to platelet activation and endothelial cell stimulation by SARS-CoV-2 binding with ACE2 receptor. Consumptive thrombocytopenia is also related to platelet activation. Elevation of sP-selectin and thrombocytopenia are related to COVID-19 complication and often correlated with severity of COVID-19.Purpose: Assess the correlation between sP-selectin and platelet in COVID-19 patients at intensive care and non-intensive care.Patients and Methods: The study population was hospitalized COVID-19 patients confirmed by Real-Time PCR that underwent platelet examination within 48 hours upon admission, divided into intensive care and non-intensive care group. sP-selectin examination using ELISA methods. Platelet cell count and sP-selectin divided based on normal reference range.Results: The subjects consist of 24 were in intensive care, 25 were in non-intensive care group. A 66.7% of subject in intensive care group has an elevation in sP-selection (> 44.0 ng/mL). Thrombocytopenia was significantly correlated with intensive group (r =− 0.32, p< 0.05). The combination of platelet count < 150.000/mm3 and sP-selectin > 44.0ng/mL was not correlated with the intensive and non-intensive group. Platelet and sP-selectin were not correlated with each other.Conclusion: Thrombocytopenia is able to induce the expression of sP-selectin.Keywords: COVID-19, sP-selectin, platelet, thrombocytopenia |
| first_indexed | 2024-03-11T15:10:01Z |
| format | Article |
| id | doaj.art-9d256d6effca4bed860e0f2534472d99 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-03-11T15:10:01Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-9d256d6effca4bed860e0f2534472d992023-10-29T18:02:23ZengDove Medical PressJournal of Blood Medicine1179-27362023-10-01Volume 1455556187681The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java IndonesiaPrihatni DBudianto FCAndriyoko BTrisa SDelita Prihatni,1 Frany Charisma Budianto,1 Basti Andriyoko,1 Suryarini Trisa2 1Clinical Pathology Department, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 2Depati Hamzah Hospital, Bangka Belitung, IndonesiaCorrespondence: Delita Prihatni, Hasan Sadikin Hospital, Jln. Pasteur No. 38, Bandung, West Java, Indonesia, Tel +628122314089, Email delita.prihatni@unpad.ac.idIntroduction: sP-selectin is a glycoprotein located in α granules of platelet and endothelial’s Weibel Palade body, as expression to platelet activation and endothelial cell stimulation by SARS-CoV-2 binding with ACE2 receptor. Consumptive thrombocytopenia is also related to platelet activation. Elevation of sP-selectin and thrombocytopenia are related to COVID-19 complication and often correlated with severity of COVID-19.Purpose: Assess the correlation between sP-selectin and platelet in COVID-19 patients at intensive care and non-intensive care.Patients and Methods: The study population was hospitalized COVID-19 patients confirmed by Real-Time PCR that underwent platelet examination within 48 hours upon admission, divided into intensive care and non-intensive care group. sP-selectin examination using ELISA methods. Platelet cell count and sP-selectin divided based on normal reference range.Results: The subjects consist of 24 were in intensive care, 25 were in non-intensive care group. A 66.7% of subject in intensive care group has an elevation in sP-selection (> 44.0 ng/mL). Thrombocytopenia was significantly correlated with intensive group (r =− 0.32, p< 0.05). The combination of platelet count < 150.000/mm3 and sP-selectin > 44.0ng/mL was not correlated with the intensive and non-intensive group. Platelet and sP-selectin were not correlated with each other.Conclusion: Thrombocytopenia is able to induce the expression of sP-selectin.Keywords: COVID-19, sP-selectin, platelet, thrombocytopeniahttps://www.dovepress.com/the-correlation-between-sp-selectin-and-platelet-count-in-covid-19-pat-peer-reviewed-fulltext-article-JBMcovid-19sp-selectinplateletthrombocytopenia. |
| spellingShingle | Prihatni D Budianto FC Andriyoko B Trisa S The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia Journal of Blood Medicine covid-19 sp-selectin platelet thrombocytopenia. |
| title | The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia |
| title_full | The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia |
| title_fullStr | The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia |
| title_full_unstemmed | The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia |
| title_short | The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia |
| title_sort | correlation between sp selectin and platelet count in covid 19 patients in referral hospital west java indonesia |
| topic | covid-19 sp-selectin platelet thrombocytopenia. |
| url | https://www.dovepress.com/the-correlation-between-sp-selectin-and-platelet-count-in-covid-19-pat-peer-reviewed-fulltext-article-JBM |
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