The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study
Background Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear. Methods In the Rotterdam Study (n = 257...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-024-02698-1 |
| _version_ | 1797273543227998208 |
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| author | Tianqi Lu Lies Lahousse Sara Wijnant Jinluan Chen Guy G. Brusselle Mandy van Hoek M. Carola Zillikens |
| author_facet | Tianqi Lu Lies Lahousse Sara Wijnant Jinluan Chen Guy G. Brusselle Mandy van Hoek M. Carola Zillikens |
| author_sort | Tianqi Lu |
| collection | DOAJ |
| description | Background Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear. Methods In the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV1 and lung diffusing capacity (DLCOc and DLCOc /alveolar volume [VA]) were measured. Associations of SAF with asthma, COPD, GOLD stage, and lung function were analyzed using logistic and linear regression adjusted for covariates, followed by interaction and stratification analyses. sRAGE and EN-RAGE associations with COPD prevalence were analyzed by logistic regression. Results SAF associated with COPD prevalence (OR = 1.299 [1.060, 1.591]) but not when adjusted for smoking (OR = 1.106 [0.89, 1.363]). SAF associated with FEV1% predicted (β=-3.384 [-4.877, -1.892]), DLCOc (β=-0.212 [-0.327, -0.097]) and GOLD stage (OR = 4.073, p = 0.001, stage 3&4 versus 1). Stratified, the association between SAF and FEV1%predicted was stronger in COPD (β=-6.362 [-9.055, -3.670]) than non-COPD (β=-1.712 [-3.306, -0.118]). Association of SAF with DLCOc and DLCOc/VA were confined to COPD (β=-0.550 [-0.909, -0.191]; β=-0.065 [-0.117, -0.014] respectively). SAF interacted with former smoking and COPD prevalence for associations with lung function. Lower sRAGE and higher EN-RAGE associated with COPD prevalence (OR = 0.575[0.354, 0.931]; OR = 1.778[1.142, 2.768], respectively). Conclusions Associations between SAF, lung function and COPD prevalence were strongly influenced by smoking. SAF associated with COPD severity and its association with lung function was more prominent within COPD. These results fuel further research into interrelations and causality between SAF, smoking and COPD. Take-home message Skin AGEs associated with prevalence and severity of COPD and lung function in the general population with a stronger effect in COPD, calling for further research into interrelations and causality between SAF, smoking and COPD. |
| first_indexed | 2024-03-07T14:44:54Z |
| format | Article |
| id | doaj.art-9d264901351b4d9abb2ce8b66a47e855 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-07T14:44:54Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-9d264901351b4d9abb2ce8b66a47e8552024-03-05T20:02:36ZengBMCRespiratory Research1465-993X2024-02-0125111010.1186/s12931-024-02698-1The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam studyTianqi Lu0Lies Lahousse1Sara Wijnant2Jinluan Chen3Guy G. Brusselle4Mandy van Hoek5M. Carola Zillikens6Department of Internal Medicine, Erasmus University Medical CenterDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Respiratory Medicine, Ghent University HospitalDepartment of Internal Medicine, Erasmus University Medical CenterDepartment of Respiratory Medicine, Ghent University HospitalDepartment of Internal Medicine, Erasmus University Medical CenterDepartment of Internal Medicine, Erasmus University Medical CenterBackground Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma is unclear. Methods In the Rotterdam Study (n = 2577), AGEs (by skin autofluorescence (SAF)), FEV1 and lung diffusing capacity (DLCOc and DLCOc /alveolar volume [VA]) were measured. Associations of SAF with asthma, COPD, GOLD stage, and lung function were analyzed using logistic and linear regression adjusted for covariates, followed by interaction and stratification analyses. sRAGE and EN-RAGE associations with COPD prevalence were analyzed by logistic regression. Results SAF associated with COPD prevalence (OR = 1.299 [1.060, 1.591]) but not when adjusted for smoking (OR = 1.106 [0.89, 1.363]). SAF associated with FEV1% predicted (β=-3.384 [-4.877, -1.892]), DLCOc (β=-0.212 [-0.327, -0.097]) and GOLD stage (OR = 4.073, p = 0.001, stage 3&4 versus 1). Stratified, the association between SAF and FEV1%predicted was stronger in COPD (β=-6.362 [-9.055, -3.670]) than non-COPD (β=-1.712 [-3.306, -0.118]). Association of SAF with DLCOc and DLCOc/VA were confined to COPD (β=-0.550 [-0.909, -0.191]; β=-0.065 [-0.117, -0.014] respectively). SAF interacted with former smoking and COPD prevalence for associations with lung function. Lower sRAGE and higher EN-RAGE associated with COPD prevalence (OR = 0.575[0.354, 0.931]; OR = 1.778[1.142, 2.768], respectively). Conclusions Associations between SAF, lung function and COPD prevalence were strongly influenced by smoking. SAF associated with COPD severity and its association with lung function was more prominent within COPD. These results fuel further research into interrelations and causality between SAF, smoking and COPD. Take-home message Skin AGEs associated with prevalence and severity of COPD and lung function in the general population with a stronger effect in COPD, calling for further research into interrelations and causality between SAF, smoking and COPD.https://doi.org/10.1186/s12931-024-02698-1Advanced glycation end products (AGEs)Skin autofluorescence (SAF)Chronic obstructive pulmonary disease (COPD)SpirometryLung function |
| spellingShingle | Tianqi Lu Lies Lahousse Sara Wijnant Jinluan Chen Guy G. Brusselle Mandy van Hoek M. Carola Zillikens The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study Respiratory Research Advanced glycation end products (AGEs) Skin autofluorescence (SAF) Chronic obstructive pulmonary disease (COPD) Spirometry Lung function |
| title | The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study |
| title_full | The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study |
| title_fullStr | The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study |
| title_full_unstemmed | The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study |
| title_short | The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study |
| title_sort | age rage axis associates with chronic pulmonary diseases and smoking in the rotterdam study |
| topic | Advanced glycation end products (AGEs) Skin autofluorescence (SAF) Chronic obstructive pulmonary disease (COPD) Spirometry Lung function |
| url | https://doi.org/10.1186/s12931-024-02698-1 |
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