Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia
Background: Pain is one of the most common postoperative complications that can be reduced via different methods like combination of two or more drugs to make synergistic effect. This research aimed to comparing the preventive effect of using combination of ketamine and fentanyl or ketamine and meto...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2015-10-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/5115 |
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| author | Seyed Mortaza Heidari-Tabaee-Zavare Mehran Qanavi Leila Raeesi |
| author_facet | Seyed Mortaza Heidari-Tabaee-Zavare Mehran Qanavi Leila Raeesi |
| author_sort | Seyed Mortaza Heidari-Tabaee-Zavare |
| collection | DOAJ |
| description | Background: Pain is one of the most common postoperative complications that can be reduced via different methods like combination of two or more drugs to make synergistic effect. This research aimed to comparing the preventive effect of using combination of ketamine and fentanyl or ketamine and metoclopramide on the postoperative pain after laparoscopic cholecystectomy.
Methods: In a double-blinded clinical trial study, 90 patients in class I and II of ASA (American Society of Anesthesiologists) classification who were candidates for laparoscopic cholecystectomy were divided into two groups. Half an hour before completion of the operation, patients in the first group received intravenous metoclopramide (0.1 mg/kg) and ketamine (0.5 mg/kg) slowly; while the patients in the second group received intravenous ketamine (0.5 mg/kg) and fentanyl (0.5 µg/kg) slowly. After completion of operation, the pain severity was evaluated based on the visual analogue score (VAS) and the data were compared between the two groups.
Findings: The main pain score in ketamine and metoclopramide group at the end of recovery, also at the 2nd, 6th, 12th, 24th postoperative hours, was significantly lower than ketamine and fentanyl group (P < 0.001).
Conclusion: Preventive administration of ketamine and metoclopramide causes more reduction in postoperative pain than ketamine and fentanyl and is not associated with any severe postoperative complication. |
| first_indexed | 2024-03-12T09:19:17Z |
| format | Article |
| id | doaj.art-9d26565c2a3c4bfaa5132b2ff3a8624d |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:19:17Z |
| publishDate | 2015-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-9d26565c2a3c4bfaa5132b2ff3a8624d2023-09-02T14:37:44ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-10-0133347135713691996Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General AnesthesiaSeyed Mortaza Heidari-Tabaee-Zavare0Mehran Qanavi1Leila Raeesi2Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranNurse Anesthetist, Operating Room, Alzahra Hospital, Isfahan, IranBackground: Pain is one of the most common postoperative complications that can be reduced via different methods like combination of two or more drugs to make synergistic effect. This research aimed to comparing the preventive effect of using combination of ketamine and fentanyl or ketamine and metoclopramide on the postoperative pain after laparoscopic cholecystectomy. Methods: In a double-blinded clinical trial study, 90 patients in class I and II of ASA (American Society of Anesthesiologists) classification who were candidates for laparoscopic cholecystectomy were divided into two groups. Half an hour before completion of the operation, patients in the first group received intravenous metoclopramide (0.1 mg/kg) and ketamine (0.5 mg/kg) slowly; while the patients in the second group received intravenous ketamine (0.5 mg/kg) and fentanyl (0.5 µg/kg) slowly. After completion of operation, the pain severity was evaluated based on the visual analogue score (VAS) and the data were compared between the two groups. Findings: The main pain score in ketamine and metoclopramide group at the end of recovery, also at the 2nd, 6th, 12th, 24th postoperative hours, was significantly lower than ketamine and fentanyl group (P < 0.001). Conclusion: Preventive administration of ketamine and metoclopramide causes more reduction in postoperative pain than ketamine and fentanyl and is not associated with any severe postoperative complication.http://jims.mui.ac.ir/index.php/jims/article/view/5115Postoperative painMetoclopramideKetamineFentanyl |
| spellingShingle | Seyed Mortaza Heidari-Tabaee-Zavare Mehran Qanavi Leila Raeesi Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia مجله دانشکده پزشکی اصفهان Postoperative pain Metoclopramide Ketamine Fentanyl |
| title | Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia |
| title_full | Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia |
| title_fullStr | Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia |
| title_full_unstemmed | Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia |
| title_short | Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia |
| title_sort | comparing the preventive effect of combination of ketamine with metoclopramide or fentanyl on the postoperative pain after laparoscopic cholecystectomy under general anesthesia |
| topic | Postoperative pain Metoclopramide Ketamine Fentanyl |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/5115 |
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