Metabolism of pancreatic cancer: paving the way to better anticancer strategies
Abstract Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pa...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-03-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-020-01169-7 |
| _version_ | 1819094809058476032 |
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| author | Cheng Qin Gang Yang Jinshou Yang Bo Ren Huanyu Wang Guangyu Chen Fangyu Zhao Lei You Weibin Wang Yupei Zhao |
| author_facet | Cheng Qin Gang Yang Jinshou Yang Bo Ren Huanyu Wang Guangyu Chen Fangyu Zhao Lei You Weibin Wang Yupei Zhao |
| author_sort | Cheng Qin |
| collection | DOAJ |
| description | Abstract Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within the tumor microenvironment contribute to unlimited pancreatic tumor progression. In addition, the metabolic reprogramming involved in pancreatic cancer resistance is also closely related to chemotherapy, radiotherapy and immunotherapy, and results in a poor prognosis. Reflective of the key role of metabolism, the number of preclinical and clinical trials about metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of pancreatic cancer patients might be largely improved after employing therapies that regulate metabolism. Thus, investigations of metabolism not only benefit the understanding of carcinogenesis and cancer progression but also provide new insights for treatments against pancreatic cancer. |
| first_indexed | 2024-12-21T23:33:18Z |
| format | Article |
| id | doaj.art-9d26b7d840914706bc6d8f9ac142d1d1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-21T23:33:18Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-9d26b7d840914706bc6d8f9ac142d1d12022-12-21T18:46:26ZengBMCMolecular Cancer1476-45982020-03-0119111910.1186/s12943-020-01169-7Metabolism of pancreatic cancer: paving the way to better anticancer strategiesCheng Qin0Gang Yang1Jinshou Yang2Bo Ren3Huanyu Wang4Guangyu Chen5Fangyu Zhao6Lei You7Weibin Wang8Yupei Zhao9Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeAbstract Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within the tumor microenvironment contribute to unlimited pancreatic tumor progression. In addition, the metabolic reprogramming involved in pancreatic cancer resistance is also closely related to chemotherapy, radiotherapy and immunotherapy, and results in a poor prognosis. Reflective of the key role of metabolism, the number of preclinical and clinical trials about metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of pancreatic cancer patients might be largely improved after employing therapies that regulate metabolism. Thus, investigations of metabolism not only benefit the understanding of carcinogenesis and cancer progression but also provide new insights for treatments against pancreatic cancer.http://link.springer.com/article/10.1186/s12943-020-01169-7Pancreatic cancerMetabolismChemoresistanceGemcitabineRadioresistanceImmunosuppression |
| spellingShingle | Cheng Qin Gang Yang Jinshou Yang Bo Ren Huanyu Wang Guangyu Chen Fangyu Zhao Lei You Weibin Wang Yupei Zhao Metabolism of pancreatic cancer: paving the way to better anticancer strategies Molecular Cancer Pancreatic cancer Metabolism Chemoresistance Gemcitabine Radioresistance Immunosuppression |
| title | Metabolism of pancreatic cancer: paving the way to better anticancer strategies |
| title_full | Metabolism of pancreatic cancer: paving the way to better anticancer strategies |
| title_fullStr | Metabolism of pancreatic cancer: paving the way to better anticancer strategies |
| title_full_unstemmed | Metabolism of pancreatic cancer: paving the way to better anticancer strategies |
| title_short | Metabolism of pancreatic cancer: paving the way to better anticancer strategies |
| title_sort | metabolism of pancreatic cancer paving the way to better anticancer strategies |
| topic | Pancreatic cancer Metabolism Chemoresistance Gemcitabine Radioresistance Immunosuppression |
| url | http://link.springer.com/article/10.1186/s12943-020-01169-7 |
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