White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation
Abstract It is well known that white blood cell (WBC) count is an independent predictor of cardiovascular events. However, associations of WBC count and WBC subtypes with endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12205-5 |
| _version_ | 1811250865648959488 |
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| author | Shinji Kishimoto Tatsuya Maruhashi Masato Kajikawa Takahiro Harada Takayuki Yamaji Yiming Han Aya Mizobuchi Yu Hashimoto Kenichi Yoshimura Yukiko Nakano Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi |
| author_facet | Shinji Kishimoto Tatsuya Maruhashi Masato Kajikawa Takahiro Harada Takayuki Yamaji Yiming Han Aya Mizobuchi Yu Hashimoto Kenichi Yoshimura Yukiko Nakano Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi |
| author_sort | Shinji Kishimoto |
| collection | DOAJ |
| description | Abstract It is well known that white blood cell (WBC) count is an independent predictor of cardiovascular events. However, associations of WBC count and WBC subtypes with endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID) are unclear. The aim of this study was to determine the relationships of WBC count and WBC subtypes with vascular function assessed by FMD and NID. A total of 1351 subjects in whom FMD and NID had been measured were recruited from Hiroshima University Vascular Registry. Mean values were 3.7 ± 2.8% for FMD and 11.8 ± 5.9% for NID. WBC was not correlated with FMD or NID. NID was significantly correlated with lymphocytes in univariate analysis but not with other hematologic parameters. In multiple linear regression analyses, NID was not correlated with lymphocytes. In all subgroups including subgroups of age, gender, body mass index, hypertension, dyslipidemia, diabetes mellitus, smoking and tertile of WBC count, WBC count was not correlated with FMD or NID. WBC count and WBC subtypes were not associated with endothelial function assessed by FMD or vascular smooth muscle function assessed by NID. WBC count and vascular function assessed by FMD and NID may reflect different aspects of atherosclerosis. Clinical Trial Registration Information: URL for Clinical Trial: http://www.umin.ac.jp Registration Number for Clinical Trial: UMIN000039512. |
| first_indexed | 2024-04-12T16:11:09Z |
| format | Article |
| id | doaj.art-9d2a066a0b6b4ffe8302dfddae01e005 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:11:09Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9d2a066a0b6b4ffe8302dfddae01e0052022-12-22T03:25:54ZengNature PortfolioScientific Reports2045-23222022-05-011211910.1038/s41598-022-12205-5White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilationShinji Kishimoto0Tatsuya Maruhashi1Masato Kajikawa2Takahiro Harada3Takayuki Yamaji4Yiming Han5Aya Mizobuchi6Yu Hashimoto7Kenichi Yoshimura8Yukiko Nakano9Kazuaki Chayama10Chikara Goto11Farina Mohamad Yusoff12Ayumu Nakashima13Yukihito Higashi14Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University HospitalDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University HospitalDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDpartment of Rehabilitation, Faculty of General Rehabilitation, Hiroshima International UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityDepartment of Stem Cell Biology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima UniversityAbstract It is well known that white blood cell (WBC) count is an independent predictor of cardiovascular events. However, associations of WBC count and WBC subtypes with endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID) are unclear. The aim of this study was to determine the relationships of WBC count and WBC subtypes with vascular function assessed by FMD and NID. A total of 1351 subjects in whom FMD and NID had been measured were recruited from Hiroshima University Vascular Registry. Mean values were 3.7 ± 2.8% for FMD and 11.8 ± 5.9% for NID. WBC was not correlated with FMD or NID. NID was significantly correlated with lymphocytes in univariate analysis but not with other hematologic parameters. In multiple linear regression analyses, NID was not correlated with lymphocytes. In all subgroups including subgroups of age, gender, body mass index, hypertension, dyslipidemia, diabetes mellitus, smoking and tertile of WBC count, WBC count was not correlated with FMD or NID. WBC count and WBC subtypes were not associated with endothelial function assessed by FMD or vascular smooth muscle function assessed by NID. WBC count and vascular function assessed by FMD and NID may reflect different aspects of atherosclerosis. Clinical Trial Registration Information: URL for Clinical Trial: http://www.umin.ac.jp Registration Number for Clinical Trial: UMIN000039512.https://doi.org/10.1038/s41598-022-12205-5 |
| spellingShingle | Shinji Kishimoto Tatsuya Maruhashi Masato Kajikawa Takahiro Harada Takayuki Yamaji Yiming Han Aya Mizobuchi Yu Hashimoto Kenichi Yoshimura Yukiko Nakano Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation Scientific Reports |
| title | White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation |
| title_full | White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation |
| title_fullStr | White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation |
| title_full_unstemmed | White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation |
| title_short | White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation |
| title_sort | white blood cell count is not associated with flow mediated vasodilation or nitroglycerine induced vasodilation |
| url | https://doi.org/10.1038/s41598-022-12205-5 |
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