RFamide peptides in early vertebrate development
RFamides (RFa) are neuropeptides involved in many different physiological processes in vertebrates, such as reproductive behavior, pubertal activation of the reproductive endocrine axis, control of feeding behavior, and pain modulation. As research has focused mostly on their role in adult vertebrat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00203/full |
| _version_ | 1828329536009273344 |
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| author | Guro Katrine Sandvik Kjetil eHodne Trude Marie Haug Kataaki eOkubo Finn-Arne eWeltzien |
| author_facet | Guro Katrine Sandvik Kjetil eHodne Trude Marie Haug Kataaki eOkubo Finn-Arne eWeltzien |
| author_sort | Guro Katrine Sandvik |
| collection | DOAJ |
| description | RFamides (RFa) are neuropeptides involved in many different physiological processes in vertebrates, such as reproductive behavior, pubertal activation of the reproductive endocrine axis, control of feeding behavior, and pain modulation. As research has focused mostly on their role in adult vertebrates, the possible roles of these peptides during development are poorly understood. However, the few studies that exist show that RFa are expressed early in development in different vertebrate classes, perhaps mostly associated with the central nervous system. Interestingly, the related peptide family of FMRFa has been shown to be important for brain development in invertebrates. In a teleost, the Japanese medaka, knockdown of genes in the Kiss system indicates that Kiss ligands and receptors are vital for brain development, but few other functional studies exist. Here we review the literature of RFa in early vertebrate development, including the possible functional roles these peptides may play. |
| first_indexed | 2024-04-13T20:26:43Z |
| format | Article |
| id | doaj.art-9d2e1346b55b414dbc92eb664fd29c5f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T20:26:43Z |
| publishDate | 2014-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9d2e1346b55b414dbc92eb664fd29c5f2022-12-22T02:31:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-12-01510.3389/fendo.2014.00203110516RFamide peptides in early vertebrate developmentGuro Katrine Sandvik0Kjetil eHodne1Trude Marie Haug2Kataaki eOkubo3Finn-Arne eWeltzien4Norwegian University of Life Sciences (NMBU)Oslo University HospitalUniversity of OsloGraduate School of Agricultural and Life Sciences, The University of TokyoNorwegian University of Life Sciences (NMBU)RFamides (RFa) are neuropeptides involved in many different physiological processes in vertebrates, such as reproductive behavior, pubertal activation of the reproductive endocrine axis, control of feeding behavior, and pain modulation. As research has focused mostly on their role in adult vertebrates, the possible roles of these peptides during development are poorly understood. However, the few studies that exist show that RFa are expressed early in development in different vertebrate classes, perhaps mostly associated with the central nervous system. Interestingly, the related peptide family of FMRFa has been shown to be important for brain development in invertebrates. In a teleost, the Japanese medaka, knockdown of genes in the Kiss system indicates that Kiss ligands and receptors are vital for brain development, but few other functional studies exist. Here we review the literature of RFa in early vertebrate development, including the possible functional roles these peptides may play.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00203/fullGnIHBrain DevelopmentPrRPearly developmentKissRFa |
| spellingShingle | Guro Katrine Sandvik Kjetil eHodne Trude Marie Haug Kataaki eOkubo Finn-Arne eWeltzien RFamide peptides in early vertebrate development Frontiers in Endocrinology GnIH Brain Development PrRP early development Kiss RFa |
| title | RFamide peptides in early vertebrate development |
| title_full | RFamide peptides in early vertebrate development |
| title_fullStr | RFamide peptides in early vertebrate development |
| title_full_unstemmed | RFamide peptides in early vertebrate development |
| title_short | RFamide peptides in early vertebrate development |
| title_sort | rfamide peptides in early vertebrate development |
| topic | GnIH Brain Development PrRP early development Kiss RFa |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00203/full |
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