Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Early detection and treatment response monitoring of HCC are vital for improved outcomes. Traditional diagnostic methods rely on imaging, serum tumor markers, and invasive liver tissue biopsy. The advent of liquid b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2023-07-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5933&vmd=Full |
| _version_ | 1797263477697413120 |
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| author | Jumi Kang Soon Sun Kim |
| author_facet | Jumi Kang Soon Sun Kim |
| author_sort | Jumi Kang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Early detection and treatment response monitoring of HCC are vital for improved outcomes. Traditional diagnostic methods rely on imaging, serum tumor markers, and invasive liver tissue biopsy. The advent of liquid biopsy has revolutionized cancer diagnostics and management. Liquid biopsy involves the detection and analysis of tumor-derived components, such as circulating tumor DNA, circulating tumor cells, and extracellular vesicles, in various body fluids. These components reflect tumor characteristics, genetic alterations, and functional changes, providing valuable information for HCC diagnosis and treatment response monitoring. Liquid biopsy offers several advantages, including its non-invasive nature, potential for repetitive sampling, and real-time monitoring of disease progression and treatment response. However, challenges remain, including the sensitivity of detection methods, and standardization. In this review, we discuss the methods, current status, and prospects of liquid biopsy for HCC, highlighting its potential as a valuable tool in HCC management. |
| first_indexed | 2024-04-25T00:13:38Z |
| format | Article |
| id | doaj.art-9d2e4d7026f74f678958eefb42ea3c07 |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-04-25T00:13:38Z |
| publishDate | 2023-07-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-9d2e4d7026f74f678958eefb42ea3c072024-03-13T07:44:26ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692023-07-018211910.4166/kjg.2023.076Current Status and Prospects of Liquid Biopsy for Hepatocellular CarcinomaJumi Kang0Soon Sun Kim1https://orcid.org/0000-0002-6862-1896Department of Gastroenterology, Ajou University School of Medicine, Suwon, KoreaDepartment of Gastroenterology, Ajou University School of Medicine, Suwon, KoreaHepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. Early detection and treatment response monitoring of HCC are vital for improved outcomes. Traditional diagnostic methods rely on imaging, serum tumor markers, and invasive liver tissue biopsy. The advent of liquid biopsy has revolutionized cancer diagnostics and management. Liquid biopsy involves the detection and analysis of tumor-derived components, such as circulating tumor DNA, circulating tumor cells, and extracellular vesicles, in various body fluids. These components reflect tumor characteristics, genetic alterations, and functional changes, providing valuable information for HCC diagnosis and treatment response monitoring. Liquid biopsy offers several advantages, including its non-invasive nature, potential for repetitive sampling, and real-time monitoring of disease progression and treatment response. However, challenges remain, including the sensitivity of detection methods, and standardization. In this review, we discuss the methods, current status, and prospects of liquid biopsy for HCC, highlighting its potential as a valuable tool in HCC management.https://www.kjg.or.kr/journal/view.html?uid=5933&vmd=Fullliquid biopsiescarcinomahepatocellulardnacirculating tumorneoplastic cellscirculatingextracellular vesicles |
| spellingShingle | Jumi Kang Soon Sun Kim Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma The Korean Journal of Gastroenterology liquid biopsies carcinoma hepatocellular dna circulating tumor neoplastic cells circulating extracellular vesicles |
| title | Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma |
| title_full | Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma |
| title_fullStr | Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma |
| title_full_unstemmed | Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma |
| title_short | Current Status and Prospects of Liquid Biopsy for Hepatocellular Carcinoma |
| title_sort | current status and prospects of liquid biopsy for hepatocellular carcinoma |
| topic | liquid biopsies carcinoma hepatocellular dna circulating tumor neoplastic cells circulating extracellular vesicles |
| url | https://www.kjg.or.kr/journal/view.html?uid=5933&vmd=Full |
| work_keys_str_mv | AT jumikang currentstatusandprospectsofliquidbiopsyforhepatocellularcarcinoma AT soonsunkim currentstatusandprospectsofliquidbiopsyforhepatocellularcarcinoma |