Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma
Magnesium alloys are considered one of the most promising materials for biodegradable trauma implants because they promote bone healing and exhibit adequate mechanical strength during their biodegradation in relation to the bone healing process. Surface modification of biodegradable magnesium alloys...
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MDPI AG
2023-01-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/16/2/554 |
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| author | Alexandru Streza Aurora Antoniac Veronica Manescu (Paltanea) Gheorghe Paltanea Alina Robu Horatiu Dura Liliana Verestiuc Enache Stanica Stefan Ioan Voicu Iulian Antoniac Mihai Bogdan Cristea Bogdan Radu Dragomir Julietta V. Rau Maria-Magdalena Manolea |
| author_facet | Alexandru Streza Aurora Antoniac Veronica Manescu (Paltanea) Gheorghe Paltanea Alina Robu Horatiu Dura Liliana Verestiuc Enache Stanica Stefan Ioan Voicu Iulian Antoniac Mihai Bogdan Cristea Bogdan Radu Dragomir Julietta V. Rau Maria-Magdalena Manolea |
| author_sort | Alexandru Streza |
| collection | DOAJ |
| description | Magnesium alloys are considered one of the most promising materials for biodegradable trauma implants because they promote bone healing and exhibit adequate mechanical strength during their biodegradation in relation to the bone healing process. Surface modification of biodegradable magnesium alloys is an important research field that is analyzed in many publications as the biodegradation due to the corrosion process and the interface with human tissue is improved. The aim of the current preliminary study is to develop a polymeric-based composite coating on biodegradable magnesium alloys by the solvent evaporation method to reduce the biodegradation rate much more than in the case of simple polymeric coatings by involving some bioactive filler in the form of particles consisting of hydroxyapatite and magnesium. Various techniques such as SEM coupled with EDS, FTIR, and RAMAN spectroscopy, and contact angle were used for the structural and morphological characterization of the coatings. In addition, thermogravimetric analysis (TGA) was used to study the effect of filler particles on polymer thermostability. In vitro cytotoxicity assays were performed on MG-63 cells (human osteosarcomas). The experimental analysis highlights the positive effect of magnesium and hydroxyapatite particles as filler for cellulose acetate when they are used alone from biocompatibility and surface analysis points of view, and it is not recommended to use both types of particles (hydroxyapatite and magnesium) as hybrid filling. In future studies focused on implantation testing, we will use only CA-based composite coatings with one filler on magnesium alloys because these composite coatings have shown better results from the in vitro testing point of view for future potential orthopedic biodegradable implants for trauma. |
| first_indexed | 2024-03-09T11:51:41Z |
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| id | doaj.art-9d3078a3792a4fd0b6b7f6589ddc19fb |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T11:51:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-9d3078a3792a4fd0b6b7f6589ddc19fb2023-11-30T23:14:53ZengMDPI AGMaterials1996-19442023-01-0116255410.3390/ma16020554Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for TraumaAlexandru Streza0Aurora Antoniac1Veronica Manescu (Paltanea)2Gheorghe Paltanea3Alina Robu4Horatiu Dura5Liliana Verestiuc6Enache Stanica7Stefan Ioan Voicu8Iulian Antoniac9Mihai Bogdan Cristea10Bogdan Radu Dragomir11Julietta V. Rau12Maria-Magdalena Manolea13Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Electrical Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 10 Victoriei Boulevard, 550024 Sibiu, RomaniaFaculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaNational Institute for Cryogenics and Isotopic Technologies ICSI-Rm. Valcea, ICSI Energy, 4 Uzinei Street, 240050 Râmnicu Vâlcea, RomaniaFaculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, District 1, 011061 Bucharest, RomaniaFaculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, RomaniaDepartment of Morphological Sciences, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, RomaniaFaculty of Dental Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, ItalyDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, RomaniaMagnesium alloys are considered one of the most promising materials for biodegradable trauma implants because they promote bone healing and exhibit adequate mechanical strength during their biodegradation in relation to the bone healing process. Surface modification of biodegradable magnesium alloys is an important research field that is analyzed in many publications as the biodegradation due to the corrosion process and the interface with human tissue is improved. The aim of the current preliminary study is to develop a polymeric-based composite coating on biodegradable magnesium alloys by the solvent evaporation method to reduce the biodegradation rate much more than in the case of simple polymeric coatings by involving some bioactive filler in the form of particles consisting of hydroxyapatite and magnesium. Various techniques such as SEM coupled with EDS, FTIR, and RAMAN spectroscopy, and contact angle were used for the structural and morphological characterization of the coatings. In addition, thermogravimetric analysis (TGA) was used to study the effect of filler particles on polymer thermostability. In vitro cytotoxicity assays were performed on MG-63 cells (human osteosarcomas). The experimental analysis highlights the positive effect of magnesium and hydroxyapatite particles as filler for cellulose acetate when they are used alone from biocompatibility and surface analysis points of view, and it is not recommended to use both types of particles (hydroxyapatite and magnesium) as hybrid filling. In future studies focused on implantation testing, we will use only CA-based composite coatings with one filler on magnesium alloys because these composite coatings have shown better results from the in vitro testing point of view for future potential orthopedic biodegradable implants for trauma.https://www.mdpi.com/1996-1944/16/2/554magnesium coatingsmagnesium alloyscellulose composite |
| spellingShingle | Alexandru Streza Aurora Antoniac Veronica Manescu (Paltanea) Gheorghe Paltanea Alina Robu Horatiu Dura Liliana Verestiuc Enache Stanica Stefan Ioan Voicu Iulian Antoniac Mihai Bogdan Cristea Bogdan Radu Dragomir Julietta V. Rau Maria-Magdalena Manolea Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma Materials magnesium coatings magnesium alloys cellulose composite |
| title | Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma |
| title_full | Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma |
| title_fullStr | Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma |
| title_full_unstemmed | Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma |
| title_short | Effect of Filler Types on Cellulose-Acetate-Based Composite Used as Coatings for Biodegradable Magnesium Implants for Trauma |
| title_sort | effect of filler types on cellulose acetate based composite used as coatings for biodegradable magnesium implants for trauma |
| topic | magnesium coatings magnesium alloys cellulose composite |
| url | https://www.mdpi.com/1996-1944/16/2/554 |
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