Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

Abstract Background There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic model of AD to investigate the effect of...

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Bibliographic Details
Main Authors: Adele Woodhouse, Carmen Maria Fernandez-Martos, Rachel Alice Kathryn Atkinson, Kelsey Anne Hanson, Jessica Marie Collins, Aidan Ryan O’Mara, Nico Terblanche, Marcus Welby Skinner, James Clement Vickers, Anna Elizabeth King
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Anesthesiology
Subjects:
Alzheimer’s disease
β-amyloid plaques
Synapse
Synaptophysin
Glutamic acid decarboxylase
Online Access:http://link.springer.com/article/10.1186/s12871-018-0509-5

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