Medium-thickness-dependent proton dosimetry for radiobiological experiments
Abstract A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-48100-9 |
| _version_ | 1818346638395047936 |
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| author | Mehrdad Shahmohammadi Beni Dragana Krstic Dragoslav Nikezic Kwan Ngok Yu |
| author_facet | Mehrdad Shahmohammadi Beni Dragana Krstic Dragoslav Nikezic Kwan Ngok Yu |
| author_sort | Mehrdad Shahmohammadi Beni |
| collection | DOAJ |
| description | Abstract A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear energy transfer (LET) of protons could rise to a sharp peak (known as the Bragg peak) towards the end of their ranges. Relationships between the calibration coefficient R vs medium-layer thickness were obtained for incident proton energies of 10, 15, 20, 25, 30 and 35 MeV, and for various medium thicknesses up to 5000 μm, where R was defined as the ratio D A /D E , D A was the absorbed proton dose in cellular components, and D E was the absorbed proton dose in a separate radiation detector. In the present work, D A and D E were determined using the MCNPX (Monte Carlo N-Particle eXtended) code version 2.4.0. For lower incident proton energies (i.e., 10, 15 and 20 MeV), formation of Bragg-peak-like features were noticed in their R-vs-medium-layer-thickness relationships, and large R values of >7 and >6 were obtained for cytoplasm and nucleus of cells, respectively, which highlighted the importance of careful consideration of the medium thickness in radiobiological experiments. |
| first_indexed | 2024-12-13T17:21:27Z |
| format | Article |
| id | doaj.art-9d33fe6b9fe5470cac8b48bdc98eea47 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:21:27Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9d33fe6b9fe5470cac8b48bdc98eea472022-12-21T23:37:17ZengNature PortfolioScientific Reports2045-23222019-08-01911710.1038/s41598-019-48100-9Medium-thickness-dependent proton dosimetry for radiobiological experimentsMehrdad Shahmohammadi Beni0Dragana Krstic1Dragoslav Nikezic2Kwan Ngok Yu3Department of Physics, City University of Hong KongFaculty of Science, University of KragujevacDepartment of Physics, City University of Hong KongDepartment of Physics, City University of Hong KongAbstract A calibration method was proposed in the present work to determine the medium-thickness-dependent proton doses absorbed in cellular components (i.e., cellular cytoplasm and nucleus) in radiobiological experiments. Consideration of the dependency on medium thickness was crucial as the linear energy transfer (LET) of protons could rise to a sharp peak (known as the Bragg peak) towards the end of their ranges. Relationships between the calibration coefficient R vs medium-layer thickness were obtained for incident proton energies of 10, 15, 20, 25, 30 and 35 MeV, and for various medium thicknesses up to 5000 μm, where R was defined as the ratio D A /D E , D A was the absorbed proton dose in cellular components, and D E was the absorbed proton dose in a separate radiation detector. In the present work, D A and D E were determined using the MCNPX (Monte Carlo N-Particle eXtended) code version 2.4.0. For lower incident proton energies (i.e., 10, 15 and 20 MeV), formation of Bragg-peak-like features were noticed in their R-vs-medium-layer-thickness relationships, and large R values of >7 and >6 were obtained for cytoplasm and nucleus of cells, respectively, which highlighted the importance of careful consideration of the medium thickness in radiobiological experiments.https://doi.org/10.1038/s41598-019-48100-9 |
| spellingShingle | Mehrdad Shahmohammadi Beni Dragana Krstic Dragoslav Nikezic Kwan Ngok Yu Medium-thickness-dependent proton dosimetry for radiobiological experiments Scientific Reports |
| title | Medium-thickness-dependent proton dosimetry for radiobiological experiments |
| title_full | Medium-thickness-dependent proton dosimetry for radiobiological experiments |
| title_fullStr | Medium-thickness-dependent proton dosimetry for radiobiological experiments |
| title_full_unstemmed | Medium-thickness-dependent proton dosimetry for radiobiological experiments |
| title_short | Medium-thickness-dependent proton dosimetry for radiobiological experiments |
| title_sort | medium thickness dependent proton dosimetry for radiobiological experiments |
| url | https://doi.org/10.1038/s41598-019-48100-9 |
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