Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation.

Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation.

During eukaryotic DNA replication, DNA polymerase alpha/primase (Pol α) initiates synthesis on both the leading and lagging strands. It is unknown whether leading- and lagging-strand priming are mechanistically identical, and whether Pol α associates processively or distributively with the replisome...

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Bibliographic Details
Main Authors: Sarina Y Porcella, Natasha C Koussa, Colin P Tang, Daphne N Kramer, Priyanka Srivastava, Duncan J Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008755

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