Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration
The non-surgical treatments are being required to reconstruct damaged tissue, prioritizing our body’s natural healing process. Thus, the use of bioactive materials such as bioactive glass has been studied to support the repair and restoration of hard and soft tissue. Thus, in this work Bioglass 45S5...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/19/2717 |
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| author | Sílvia Rodrigues Gavinho Ana Sofia Pádua Laura Isabel Vilas Holz Isabel Sá-Nogueira Jorge Carvalho Silva João Paulo Borges Manuel Almeida Valente Manuel Pedro Fernandes Graça |
| author_facet | Sílvia Rodrigues Gavinho Ana Sofia Pádua Laura Isabel Vilas Holz Isabel Sá-Nogueira Jorge Carvalho Silva João Paulo Borges Manuel Almeida Valente Manuel Pedro Fernandes Graça |
| author_sort | Sílvia Rodrigues Gavinho |
| collection | DOAJ |
| description | The non-surgical treatments are being required to reconstruct damaged tissue, prioritizing our body’s natural healing process. Thus, the use of bioactive materials such as bioactive glass has been studied to support the repair and restoration of hard and soft tissue. Thus, in this work Bioglass 45S5 was developed, adding 1 and 2%mol of SrO or MgO and the physical and biological properties were evaluated. The addition of MgO and SrO at the studied concentrations promoted the slight increase in non-bridging oxygens number, observed through the temperature shift in phase transitions to lower values compared to Bioglass 45S5. The insertion of the ions also showed a positive effect on Saos-2 cell viability, decreasing the cytotoxic of Bioglass 45S5. Besides the Ca/P ratio on the pellets surface demonstrating no evidence of higher reactivity between Bioglass 45S5 and Bioglass with Sr and Mg, micrographs show that at 24 h the Ca/P rich layer is denser than in Bioglass 45S5 after the contact with simulated body fluid. The samples with Sr and Mg show a higher antibacterial effect compared to Bioglass 45S5. The addition of the studied ions may benefit the biological response of Bioglass 45S5 in dental applications as scaffolds or coatings. |
| first_indexed | 2024-03-10T21:38:54Z |
| format | Article |
| id | doaj.art-9d3a330997324167aae3be3d1151f799 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T21:38:54Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-9d3a330997324167aae3be3d1151f7992023-11-19T14:49:50ZengMDPI AGNanomaterials2079-49912023-10-011319271710.3390/nano13192717Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone RegenerationSílvia Rodrigues Gavinho0Ana Sofia Pádua1Laura Isabel Vilas Holz2Isabel Sá-Nogueira3Jorge Carvalho Silva4João Paulo Borges5Manuel Almeida Valente6Manuel Pedro Fernandes Graça7I3N and Physics Department, Aveiro University, 3810-193 Aveiro, PortugalI3N-CENIMAT and Physics Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, PortugalTEMA and Mechanical Engineering Department, Aveiro University, 3810-193 Aveiro, PortugalAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, PortugalI3N-CENIMAT and Physics Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, PortugalI3N-CENIMAT and Materials Science Department, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, PortugalI3N and Physics Department, Aveiro University, 3810-193 Aveiro, PortugalI3N and Physics Department, Aveiro University, 3810-193 Aveiro, PortugalThe non-surgical treatments are being required to reconstruct damaged tissue, prioritizing our body’s natural healing process. Thus, the use of bioactive materials such as bioactive glass has been studied to support the repair and restoration of hard and soft tissue. Thus, in this work Bioglass 45S5 was developed, adding 1 and 2%mol of SrO or MgO and the physical and biological properties were evaluated. The addition of MgO and SrO at the studied concentrations promoted the slight increase in non-bridging oxygens number, observed through the temperature shift in phase transitions to lower values compared to Bioglass 45S5. The insertion of the ions also showed a positive effect on Saos-2 cell viability, decreasing the cytotoxic of Bioglass 45S5. Besides the Ca/P ratio on the pellets surface demonstrating no evidence of higher reactivity between Bioglass 45S5 and Bioglass with Sr and Mg, micrographs show that at 24 h the Ca/P rich layer is denser than in Bioglass 45S5 after the contact with simulated body fluid. The samples with Sr and Mg show a higher antibacterial effect compared to Bioglass 45S5. The addition of the studied ions may benefit the biological response of Bioglass 45S5 in dental applications as scaffolds or coatings.https://www.mdpi.com/2079-4991/13/19/2717bioactive glassmagnesiumstrontiumantibacterial activitybioactivitydental applications |
| spellingShingle | Sílvia Rodrigues Gavinho Ana Sofia Pádua Laura Isabel Vilas Holz Isabel Sá-Nogueira Jorge Carvalho Silva João Paulo Borges Manuel Almeida Valente Manuel Pedro Fernandes Graça Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration Nanomaterials bioactive glass magnesium strontium antibacterial activity bioactivity dental applications |
| title | Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration |
| title_full | Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration |
| title_fullStr | Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration |
| title_full_unstemmed | Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration |
| title_short | Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration |
| title_sort | bioactive glasses containing strontium or magnesium ions to enhance the biological response in bone regeneration |
| topic | bioactive glass magnesium strontium antibacterial activity bioactivity dental applications |
| url | https://www.mdpi.com/2079-4991/13/19/2717 |
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