Acute microglia ablation induces neurodegeneration in the somatosensory system
Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory comp...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05929-4 |
| _version_ | 1818978268616851456 |
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| author | Stephen J. Rubino Lior Mayo Isabella Wimmer Victoria Siedler Florian Brunner Simon Hametner Asaf Madi Amanda Lanser Thais Moreira Dustin Donnelly Laura Cox Rafael Machado Rezende Oleg Butovsky Hans Lassmann Howard L. Weiner |
| author_facet | Stephen J. Rubino Lior Mayo Isabella Wimmer Victoria Siedler Florian Brunner Simon Hametner Asaf Madi Amanda Lanser Thais Moreira Dustin Donnelly Laura Cox Rafael Machado Rezende Oleg Butovsky Hans Lassmann Howard L. Weiner |
| author_sort | Stephen J. Rubino |
| collection | DOAJ |
| description | Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory components that may contribute. |
| first_indexed | 2024-12-20T16:40:56Z |
| format | Article |
| id | doaj.art-9d3a63c0ded44732a54cfe43f20342b8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:40:56Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9d3a63c0ded44732a54cfe43f20342b82022-12-21T19:33:02ZengNature PortfolioNature Communications2041-17232018-11-019111310.1038/s41467-018-05929-4Acute microglia ablation induces neurodegeneration in the somatosensory systemStephen J. Rubino0Lior Mayo1Isabella Wimmer2Victoria Siedler3Florian Brunner4Simon Hametner5Asaf Madi6Amanda Lanser7Thais Moreira8Dustin Donnelly9Laura Cox10Rafael Machado Rezende11Oleg Butovsky12Hans Lassmann13Howard L. Weiner14Ann Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Neuroimmunology, Medical University of ViennaDepartment of Neuroimmunology, Medical University of ViennaDepartment of Neuroimmunology, Medical University of ViennaDepartment of Neuroimmunology, Medical University of ViennaEvergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Neuroimmunology, Medical University of ViennaAnn Romney Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Medical SchoolPrevious studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory components that may contribute.https://doi.org/10.1038/s41467-018-05929-4 |
| spellingShingle | Stephen J. Rubino Lior Mayo Isabella Wimmer Victoria Siedler Florian Brunner Simon Hametner Asaf Madi Amanda Lanser Thais Moreira Dustin Donnelly Laura Cox Rafael Machado Rezende Oleg Butovsky Hans Lassmann Howard L. Weiner Acute microglia ablation induces neurodegeneration in the somatosensory system Nature Communications |
| title | Acute microglia ablation induces neurodegeneration in the somatosensory system |
| title_full | Acute microglia ablation induces neurodegeneration in the somatosensory system |
| title_fullStr | Acute microglia ablation induces neurodegeneration in the somatosensory system |
| title_full_unstemmed | Acute microglia ablation induces neurodegeneration in the somatosensory system |
| title_short | Acute microglia ablation induces neurodegeneration in the somatosensory system |
| title_sort | acute microglia ablation induces neurodegeneration in the somatosensory system |
| url | https://doi.org/10.1038/s41467-018-05929-4 |
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