Silicone Implants Immobilized with Interleukin-4 Promote the M2 Polarization of Macrophages and Inhibit the Formation of Fibrous Capsules

Silicone Implants Immobilized with Interleukin-4 Promote the M2 Polarization of Macrophages and Inhibit the Formation of Fibrous Capsules

Breast augmentations with silicone implants can have adverse effects on tissues that, in turn, lead to capsular contracture (CC). One of the potential ways of overcoming CC is to control the implant/host interaction using immunomodulatory agents. Recently, a high ratio of anti-inflammatory (M2) macr...

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Bibliographic Details
Main Authors: Hyun-Seok Kim, Seongsoo Kim, Byung-Ho Shin, Chan-Yeong Heo, Omar Faruq, Le Thi Van Anh, Nilsu Dönmez, Pham Ngoc Chien, Dong-Sik Shin, Sun-Young Nam, Rong-Min Baek
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Polymers
Subjects:
silicone implants
immobilization of IL-4
capsular contracture
fibrosis
inflammation
macrophage polarization
Online Access:https://www.mdpi.com/2073-4360/13/16/2630

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