Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity

Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity

IntroductionPsoriasis is a T-cell mediated autoimmune skin disease. HLA-C*06:02 is the main psoriasis-specific risk gene. Using a Vα3S1/Vβ13S1 T-cell receptor (TCR) from a lesional psoriatic CD8+ T-cell clone we had discovered that, as an underlying pathomechanism, HLA-C*06:02 mediates an autoimmune...

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Main Authors: Tatsushi Ishimoto, Yukiyasu Arakawa, Secil Vural, Julia Stöhr, Sigrid Vollmer, Adrian Galinski, Katherina Siewert, Geraldine Rühl, Yuri Poluektov, Marc Delcommenne, Orsolya Horvath, Mengwen He, Burkhard Summer, Ralf Pohl, Rehab Alharbi, Klaus Dornmair, Akiko Arakawa, Jörg C. Prinz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
psoriasis
pathogenic T-cell receptor
T-cell receptor polyspecificity
autoimmune response
environmental antigens
diseases triggers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374581/full

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