Role of the complement system in the tumor microenvironment
Abstract The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (TME). The TME plays crucial roles in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-019-1027-3 |
| _version_ | 1819208942163591168 |
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| author | Ronghua Zhang Qiaofei Liu Tong Li Quan Liao Yupei Zhao |
| author_facet | Ronghua Zhang Qiaofei Liu Tong Li Quan Liao Yupei Zhao |
| author_sort | Ronghua Zhang |
| collection | DOAJ |
| description | Abstract The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (TME). The TME plays crucial roles in tumorigenesis, progression, metastasis and recurrence. Imbalanced complement activation and the deposition of complement proteins have been demonstrated in many types of tumors. Plasma proteins, receptors, and regulators of complement activation regulate several biological functions of stromal cells in the TME and promote the malignant biological properties of tumors. Interactions between the complement system and cancer cells contribute to the proliferation, epithelial-mesenchymal transition, migration and invasion of tumor cells. In this review, we summarize recent advances related to the function of the complement system in the TME and discuss the therapeutic potential of targeting complement-mediated immunoregulation in cancer immunotherapy. |
| first_indexed | 2024-12-23T05:47:24Z |
| format | Article |
| id | doaj.art-9d410bfe9a1d4147a3929688f5e37fef |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-23T05:47:24Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-9d410bfe9a1d4147a3929688f5e37fef2022-12-21T17:58:03ZengBMCCancer Cell International1475-28672019-11-0119111210.1186/s12935-019-1027-3Role of the complement system in the tumor microenvironmentRonghua Zhang0Qiaofei Liu1Tong Li2Quan Liao3Yupei Zhao4Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical SciencesAbstract The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (TME). The TME plays crucial roles in tumorigenesis, progression, metastasis and recurrence. Imbalanced complement activation and the deposition of complement proteins have been demonstrated in many types of tumors. Plasma proteins, receptors, and regulators of complement activation regulate several biological functions of stromal cells in the TME and promote the malignant biological properties of tumors. Interactions between the complement system and cancer cells contribute to the proliferation, epithelial-mesenchymal transition, migration and invasion of tumor cells. In this review, we summarize recent advances related to the function of the complement system in the TME and discuss the therapeutic potential of targeting complement-mediated immunoregulation in cancer immunotherapy.http://link.springer.com/article/10.1186/s12935-019-1027-3Complement systemTumor microenvironmentImmunoregulationImmunotherapy |
| spellingShingle | Ronghua Zhang Qiaofei Liu Tong Li Quan Liao Yupei Zhao Role of the complement system in the tumor microenvironment Cancer Cell International Complement system Tumor microenvironment Immunoregulation Immunotherapy |
| title | Role of the complement system in the tumor microenvironment |
| title_full | Role of the complement system in the tumor microenvironment |
| title_fullStr | Role of the complement system in the tumor microenvironment |
| title_full_unstemmed | Role of the complement system in the tumor microenvironment |
| title_short | Role of the complement system in the tumor microenvironment |
| title_sort | role of the complement system in the tumor microenvironment |
| topic | Complement system Tumor microenvironment Immunoregulation Immunotherapy |
| url | http://link.springer.com/article/10.1186/s12935-019-1027-3 |
| work_keys_str_mv | AT ronghuazhang roleofthecomplementsysteminthetumormicroenvironment AT qiaofeiliu roleofthecomplementsysteminthetumormicroenvironment AT tongli roleofthecomplementsysteminthetumormicroenvironment AT quanliao roleofthecomplementsysteminthetumormicroenvironment AT yupeizhao roleofthecomplementsysteminthetumormicroenvironment |