Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2007-01-01
|
| Series: | Biomarker Insights |
| Subjects: | |
| Online Access: | http://la-press.com/article.php?article_id=325 |
| _version_ | 1818147976760000512 |
|---|---|
| author | Stephen F. Kingsmore Ingrid E. Lindquist Joann Mudge William D. Beavis |
| author_facet | Stephen F. Kingsmore Ingrid E. Lindquist Joann Mudge William D. Beavis |
| author_sort | Stephen F. Kingsmore |
| collection | DOAJ |
| description | Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to identify genetic biomarkers in common human diseases and traits. Such studies are yielding initial insights into the allelic architecture of complex traits. In general, it appears that complex diseases are associated with many common polymorphisms, implying profound genetic heterogeneity between affected individuals. |
| first_indexed | 2024-12-11T12:43:48Z |
| format | Article |
| id | doaj.art-9d41cacdf15f4d6a8f0add715e22b0dc |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-11T12:43:48Z |
| publishDate | 2007-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-9d41cacdf15f4d6a8f0add715e22b0dc2022-12-22T01:06:53ZengSAGE PublishingBiomarker Insights1177-27192007-01-012283292Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex DiseasesStephen F. KingsmoreIngrid E. LindquistJoann MudgeWilliam D. BeavisNovel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to identify genetic biomarkers in common human diseases and traits. Such studies are yielding initial insights into the allelic architecture of complex traits. In general, it appears that complex diseases are associated with many common polymorphisms, implying profound genetic heterogeneity between affected individuals.http://la-press.com/article.php?article_id=325Genome-wide association studiesComplex diseasesComplex traitsGenetic biomarkersPopulation genetics |
| spellingShingle | Stephen F. Kingsmore Ingrid E. Lindquist Joann Mudge William D. Beavis Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases Biomarker Insights Genome-wide association studies Complex diseases Complex traits Genetic biomarkers Population genetics |
| title | Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases |
| title_full | Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases |
| title_fullStr | Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases |
| title_full_unstemmed | Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases |
| title_short | Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases |
| title_sort | genome wide association studies progress in identifying genetic biomarkers in common complex diseases |
| topic | Genome-wide association studies Complex diseases Complex traits Genetic biomarkers Population genetics |
| url | http://la-press.com/article.php?article_id=325 |
| work_keys_str_mv | AT stephenfkingsmore genomewideassociationstudiesprogressinidentifyinggeneticbiomarkersincommoncomplexdiseases AT ingridelindquist genomewideassociationstudiesprogressinidentifyinggeneticbiomarkersincommoncomplexdiseases AT joannmudge genomewideassociationstudiesprogressinidentifyinggeneticbiomarkersincommoncomplexdiseases AT williamdbeavis genomewideassociationstudiesprogressinidentifyinggeneticbiomarkersincommoncomplexdiseases |