Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications
Abstract Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the narrow spatial structure of the capsule and complex gastrointestinal tract enviro...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46046-9 |
| _version_ | 1797274113819017216 |
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| author | Yuxuan Sun Wang Zhang Junnan Gu Liangyu Xia Yinghao Cao Xinhui Zhu Hao Wen Shaowei Ouyang Ruiqi Liu Jialong Li Zhenxing Jiang Denglong Cheng Yiliang Lv Xiaotao Han Wu Qiu Kailin Cai Enmin Song Quanliang Cao Liang Li |
| author_facet | Yuxuan Sun Wang Zhang Junnan Gu Liangyu Xia Yinghao Cao Xinhui Zhu Hao Wen Shaowei Ouyang Ruiqi Liu Jialong Li Zhenxing Jiang Denglong Cheng Yiliang Lv Xiaotao Han Wu Qiu Kailin Cai Enmin Song Quanliang Cao Liang Li |
| author_sort | Yuxuan Sun |
| collection | DOAJ |
| description | Abstract Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the narrow spatial structure of the capsule and complex gastrointestinal tract environment cause many open-ended problems, such as poor active motion and limited medical functions. In this work, we describe the development of small-scale magnetically driven capsules with a distinct magnetic soft valve made of dual-layer ferromagnetic soft composite films. A core technological advancement achieved is the flexible opening and closing of the magnetic soft valve by using the competitive interactions between magnetic gradient force and magnetic torque, laying the foundation for the functional integration of both drug release and sampling. Meanwhile, we propose a magnetic actuation strategy based on multi-frequency response control and demonstrate that it can achieve effective decoupled regulation of the capsule’s global motion and local responses. Finally, through a comprehensive approach encompassing ideal models, animal ex vivo models, and in vivo assessment, we demonstrate the versatility of the developed magnetic capsules and their multiple potential applications in the biomedical field, such as targeted drug delivery and sampling, selective dual-drug release, and light/thermal-assisted therapy. |
| first_indexed | 2024-03-07T14:53:43Z |
| format | Article |
| id | doaj.art-9d41ccb1822b44a3b4f627470519cd30 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:53:43Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9d41ccb1822b44a3b4f627470519cd302024-03-05T19:34:40ZengNature PortfolioNature Communications2041-17232024-02-0115111410.1038/s41467-024-46046-9Magnetically driven capsules with multimodal response and multifunctionality for biomedical applicationsYuxuan Sun0Wang Zhang1Junnan Gu2Liangyu Xia3Yinghao Cao4Xinhui Zhu5Hao Wen6Shaowei Ouyang7Ruiqi Liu8Jialong Li9Zhenxing Jiang10Denglong Cheng11Yiliang Lv12Xiaotao Han13Wu Qiu14Kailin Cai15Enmin Song16Quanliang Cao17Liang Li18Wuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologySchool of Life Science and Technology, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologySchool of Computer and Technology, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyWuhan National High Magnetic Field Center, Huazhong University of Science and TechnologyAbstract Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the narrow spatial structure of the capsule and complex gastrointestinal tract environment cause many open-ended problems, such as poor active motion and limited medical functions. In this work, we describe the development of small-scale magnetically driven capsules with a distinct magnetic soft valve made of dual-layer ferromagnetic soft composite films. A core technological advancement achieved is the flexible opening and closing of the magnetic soft valve by using the competitive interactions between magnetic gradient force and magnetic torque, laying the foundation for the functional integration of both drug release and sampling. Meanwhile, we propose a magnetic actuation strategy based on multi-frequency response control and demonstrate that it can achieve effective decoupled regulation of the capsule’s global motion and local responses. Finally, through a comprehensive approach encompassing ideal models, animal ex vivo models, and in vivo assessment, we demonstrate the versatility of the developed magnetic capsules and their multiple potential applications in the biomedical field, such as targeted drug delivery and sampling, selective dual-drug release, and light/thermal-assisted therapy.https://doi.org/10.1038/s41467-024-46046-9 |
| spellingShingle | Yuxuan Sun Wang Zhang Junnan Gu Liangyu Xia Yinghao Cao Xinhui Zhu Hao Wen Shaowei Ouyang Ruiqi Liu Jialong Li Zhenxing Jiang Denglong Cheng Yiliang Lv Xiaotao Han Wu Qiu Kailin Cai Enmin Song Quanliang Cao Liang Li Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications Nature Communications |
| title | Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications |
| title_full | Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications |
| title_fullStr | Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications |
| title_full_unstemmed | Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications |
| title_short | Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications |
| title_sort | magnetically driven capsules with multimodal response and multifunctionality for biomedical applications |
| url | https://doi.org/10.1038/s41467-024-46046-9 |
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