Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19
Aim:The diagnostic value of inflammatory markers to determine the severity of Coronavirus disease-2019 (COVID-19) is postulated in some recent studies, but conclusions were inconsistent. Hence, we intend to examine the utility of presepsin, procalcitonin and C-reactive protein in predicting the seve...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-11-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/diagnostic-value-of-novel-presepsin-and-nflammator/49790
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| _version_ | 1797918507185209344 |
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| author | Faraz Hasan Mirza Faraz Ahmed Baig Serajuddaula Syed |
| author_facet | Faraz Hasan Mirza Faraz Ahmed Baig Serajuddaula Syed |
| author_sort | Faraz Hasan Mirza |
| collection | DOAJ |
| description | Aim:The diagnostic value of inflammatory markers to determine the severity of Coronavirus disease-2019 (COVID-19) is postulated in some recent studies, but conclusions were inconsistent. Hence, we intend to examine the utility of presepsin, procalcitonin and C-reactive protein in predicting the severity of COVID-19 infection.Methods:Single-center cross-sectional study was undertaken at the Intensive care unit of a university hospital. Eighty consecutive cases diagnosed with Severe Acute Respiratory syndrome-Coronavirus-2 RNA between October 2020 and July 2021 were classified according to the severity of the disease. Laboratory data related to Procalcitonin and C-reactive protein was retrieved from investigations coinciding with the day of admission. The stored plasma was subjected to an enzyme-linked immunosorbent assay to determine plasma presepsin levels. Statistical test for measures of screening was employed and a receiver operator curve was generated.Results:We have determined that presepsin is the most sensitive prognostic indicator (93.3%) with a strong statistical association (p<0.001) for COVID-19. 15.99 ng/L could be used as a reference level to predict the progressive clinical course. Relatively lower sensitivity (88%) and positive statistical correlation (p=0.049) of C-reactive protein with high-risk infection were also observed. Procalcitonin showed limited diagnostic and prognostic value in our series.Conclusion:Our findings seem to demonstrate the role of presepsin in providing prognostic information in COVID-19 patients. Therefore, we suggest that early monitoring of presepsin with routine marker profile might help in identifying patients suffering from a more severe disease. |
| first_indexed | 2024-04-10T13:30:19Z |
| format | Article |
| id | doaj.art-9d4219592394407cb0f2a8e5a37d93b8 |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T13:30:19Z |
| publishDate | 2021-11-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-9d4219592394407cb0f2a8e5a37d93b82023-02-15T16:11:39ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882021-11-0159535836210.4274/haseki.galenos.2021.765313049054Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19Faraz Hasan Mirza0Faraz Ahmed Baig1Serajuddaula Syed2 Ziauddin University, Department of Pathology, Karachi, Pakistan Ziauddin University, Department of Pathology, Karachi, Pakistan Ziauddin University, Department of Pathology, Karachi, Pakistan Aim:The diagnostic value of inflammatory markers to determine the severity of Coronavirus disease-2019 (COVID-19) is postulated in some recent studies, but conclusions were inconsistent. Hence, we intend to examine the utility of presepsin, procalcitonin and C-reactive protein in predicting the severity of COVID-19 infection.Methods:Single-center cross-sectional study was undertaken at the Intensive care unit of a university hospital. Eighty consecutive cases diagnosed with Severe Acute Respiratory syndrome-Coronavirus-2 RNA between October 2020 and July 2021 were classified according to the severity of the disease. Laboratory data related to Procalcitonin and C-reactive protein was retrieved from investigations coinciding with the day of admission. The stored plasma was subjected to an enzyme-linked immunosorbent assay to determine plasma presepsin levels. Statistical test for measures of screening was employed and a receiver operator curve was generated.Results:We have determined that presepsin is the most sensitive prognostic indicator (93.3%) with a strong statistical association (p<0.001) for COVID-19. 15.99 ng/L could be used as a reference level to predict the progressive clinical course. Relatively lower sensitivity (88%) and positive statistical correlation (p=0.049) of C-reactive protein with high-risk infection were also observed. Procalcitonin showed limited diagnostic and prognostic value in our series.Conclusion:Our findings seem to demonstrate the role of presepsin in providing prognostic information in COVID-19 patients. Therefore, we suggest that early monitoring of presepsin with routine marker profile might help in identifying patients suffering from a more severe disease. http://www.hasekidergisi.com/archives/archive-detail/article-preview/diagnostic-value-of-novel-presepsin-and-nflammator/49790 sars-cov-2 patientsbiomarkerspresepsinprognosis |
| spellingShingle | Faraz Hasan Mirza Faraz Ahmed Baig Serajuddaula Syed Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19 Haseki Tıp Bülteni sars-cov-2 patients biomarkers presepsin prognosis |
| title | Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19 |
| title_full | Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19 |
| title_fullStr | Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19 |
| title_full_unstemmed | Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19 |
| title_short | Diagnostic Value of Novel Presepsin and Inflammatory Biomarkers in Predicting the Clinical Course of COVID-19 |
| title_sort | diagnostic value of novel presepsin and inflammatory biomarkers in predicting the clinical course of covid 19 |
| topic | sars-cov-2 patients biomarkers presepsin prognosis |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/diagnostic-value-of-novel-presepsin-and-nflammator/49790
|
| work_keys_str_mv | AT farazhasanmirza diagnosticvalueofnovelpresepsinandinflammatorybiomarkersinpredictingtheclinicalcourseofcovid19 AT farazahmedbaig diagnosticvalueofnovelpresepsinandinflammatorybiomarkersinpredictingtheclinicalcourseofcovid19 AT serajuddaulasyed diagnosticvalueofnovelpresepsinandinflammatorybiomarkersinpredictingtheclinicalcourseofcovid19 |