Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults
The consumption of berry fruits engenders a number of benefits in animal models, including improvements in cognitive performance, slowing of cognitive decline during natural ageing, and neuroprotection. These findings, along with limited human epidemiological evidence, suggest a potential role for t...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464615002893 |
| _version_ | 1819055288080138240 |
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| author | Anthony W. Watson Crystal F. Haskell-Ramsay David O. Kennedy Janine M. Cooney Tania Trower Arjan Scheepens |
| author_facet | Anthony W. Watson Crystal F. Haskell-Ramsay David O. Kennedy Janine M. Cooney Tania Trower Arjan Scheepens |
| author_sort | Anthony W. Watson |
| collection | DOAJ |
| description | The consumption of berry fruits engenders a number of benefits in animal models, including improvements in cognitive performance, slowing of cognitive decline during natural ageing, and neuroprotection. These findings, along with limited human epidemiological evidence, suggest a potential role for the consumption of berry fruit polyphenols in improving human cognitive performance. The current study assessed the effects of two blackcurrant extracts on cognitive outcomes, mood, autonomic measures, peripheral and central monoamine tone, and anthocyanin bioavailability to plasma. A randomised, double-blind, placebo-controlled, crossover study was conducted using 36 healthy young participants (18–35 years). Findings from the intervention illustrate a cognitive benefit of acute blackcurrant supplementation in healthy young humans and the first description of a clinically significant inhibition of monoamine oxidase-B and monoamine oxidase-A using a commonly consumed fruit. These data also illustrate that compounds other than anthocyanins may be responsible for the observed in vivo MAO inhibition and that the degree of processing and the cultivar of blackcurrant fruit used substantially alter the neuroendocrinological and cognitive benefits conveyed. |
| first_indexed | 2024-12-21T13:05:08Z |
| format | Article |
| id | doaj.art-9d42a67ac5d2491a8a31b7961fe0d3dc |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-21T13:05:08Z |
| publishDate | 2015-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9d42a67ac5d2491a8a31b7961fe0d3dc2022-12-21T19:03:03ZengElsevierJournal of Functional Foods1756-46462015-08-0117524539Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adultsAnthony W. Watson0Crystal F. Haskell-Ramsay1David O. Kennedy2Janine M. Cooney3Tania Trower4Arjan Scheepens5Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle Upon-Tyne NE1 8ST, UK; The New Zealand Institute for Plant & Food Research Ltd, Auckland 1025, New Zealand; Corresponding author. Human Nutrition Research Centre, nu-food, School of Agriculture, Food and Rural Development, Agriculture Building, Newcastle University, Newcastle Upon-Tyne NE17RU, UK. Tel.: +44 01912086619; fax: +44 01912086720.Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle Upon-Tyne NE1 8ST, UKBrain, Performance and Nutrition Research Centre, Northumbria University, Newcastle Upon-Tyne NE1 8ST, UKThe New Zealand Institute for Plant & Food Research Ltd, Auckland 1025, New ZealandThe New Zealand Institute for Plant & Food Research Ltd, Auckland 1025, New ZealandThe New Zealand Institute for Plant & Food Research Ltd, Auckland 1025, New ZealandThe consumption of berry fruits engenders a number of benefits in animal models, including improvements in cognitive performance, slowing of cognitive decline during natural ageing, and neuroprotection. These findings, along with limited human epidemiological evidence, suggest a potential role for the consumption of berry fruit polyphenols in improving human cognitive performance. The current study assessed the effects of two blackcurrant extracts on cognitive outcomes, mood, autonomic measures, peripheral and central monoamine tone, and anthocyanin bioavailability to plasma. A randomised, double-blind, placebo-controlled, crossover study was conducted using 36 healthy young participants (18–35 years). Findings from the intervention illustrate a cognitive benefit of acute blackcurrant supplementation in healthy young humans and the first description of a clinically significant inhibition of monoamine oxidase-B and monoamine oxidase-A using a commonly consumed fruit. These data also illustrate that compounds other than anthocyanins may be responsible for the observed in vivo MAO inhibition and that the degree of processing and the cultivar of blackcurrant fruit used substantially alter the neuroendocrinological and cognitive benefits conveyed.http://www.sciencedirect.com/science/article/pii/S1756464615002893BlackcurrantsPhytochemicalsCognitive performanceMoodMonoamine oxidase inhibitionBlood glucose |
| spellingShingle | Anthony W. Watson Crystal F. Haskell-Ramsay David O. Kennedy Janine M. Cooney Tania Trower Arjan Scheepens Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults Journal of Functional Foods Blackcurrants Phytochemicals Cognitive performance Mood Monoamine oxidase inhibition Blood glucose |
| title | Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults |
| title_full | Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults |
| title_fullStr | Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults |
| title_full_unstemmed | Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults |
| title_short | Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults |
| title_sort | acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase b in healthy young adults |
| topic | Blackcurrants Phytochemicals Cognitive performance Mood Monoamine oxidase inhibition Blood glucose |
| url | http://www.sciencedirect.com/science/article/pii/S1756464615002893 |
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