Intramuscular vaccination against SARS-CoV-2 transiently induces neutralizing IgG rather than IgA in the saliva

Intramuscular vaccination against SARS-CoV-2 transiently induces neutralizing IgG rather than IgA in the saliva

The mucosal immunity is crucial for restricting SARS-CoV-2 at its entry site. Intramuscularly applied vaccines against SARS-CoV-2 stimulate high levels of neutralizing Abs in serum, but the impact of these intramuscular vaccinations on features of mucosal immunity is less clear. Here, we analyzed ki...

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Bibliographic Details
Main Authors: Stephan Winklmeier, Heike Rübsamen, Ceren Özdemir, Paul R. Wratil, Gaia Lupoli, Marcel Stern, Celine Schneider, Katharina Eisenhut, Samantha Ho, Hoi Kiu Wong, Damla Taskin, Marvin Petry, Michael Weigand, Peter Eichhorn, Bärbel U. Foesel, Simone Mader, Oliver T. Keppler, Tania Kümpfel, Edgar Meinl
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
viral neutralization
saliva
COVID
vaccination
IgG
IgA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330864/full

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