Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
Abstract Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate immune system, limiting the availability of free trace metals by cells of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-04-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-021-01722-y |
| _version_ | 1818562819340107776 |
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| author | Claire Healy Natalia Munoz-Wolf Janné Strydom Lynne Faherty Niamh C. Williams Sarah Kenny Seamas C. Donnelly Suzanne M. Cloonan |
| author_facet | Claire Healy Natalia Munoz-Wolf Janné Strydom Lynne Faherty Niamh C. Williams Sarah Kenny Seamas C. Donnelly Suzanne M. Cloonan |
| author_sort | Claire Healy |
| collection | DOAJ |
| description | Abstract Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate immune system, limiting the availability of free trace metals by cells of the immune system serves not only to conceal these vital nutrients from invading bacteria but also operates to tightly regulate host immune cell responses and function. In the setting of chronic lung disease, the regulation of trace metals by the host is often disrupted, leading to the altered availability of these nutrients to commensal and invading opportunistic pathogenic microbes. Similarly, alterations in the uptake, secretion, turnover and redox activity of these vitally important metals has significant repercussions for immune cell function including the response to and resolution of infection. This review will discuss the intricate role of nutritional immunity in host immune cells of the lung and how changes in this fundamental process as a result of chronic lung disease may alter the airway microbiome, disease progression and the response to infection. |
| first_indexed | 2024-12-14T01:08:44Z |
| format | Article |
| id | doaj.art-9d43924907e74518b12100ad3b6c7b41 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-14T01:08:44Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-9d43924907e74518b12100ad3b6c7b412022-12-21T23:22:50ZengBMCRespiratory Research1465-993X2021-04-0122114410.1186/s12931-021-01722-yNutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory diseaseClaire Healy0Natalia Munoz-Wolf1Janné Strydom2Lynne Faherty3Niamh C. Williams4Sarah Kenny5Seamas C. Donnelly6Suzanne M. Cloonan7School of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College DublinAbstract Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate immune system, limiting the availability of free trace metals by cells of the immune system serves not only to conceal these vital nutrients from invading bacteria but also operates to tightly regulate host immune cell responses and function. In the setting of chronic lung disease, the regulation of trace metals by the host is often disrupted, leading to the altered availability of these nutrients to commensal and invading opportunistic pathogenic microbes. Similarly, alterations in the uptake, secretion, turnover and redox activity of these vitally important metals has significant repercussions for immune cell function including the response to and resolution of infection. This review will discuss the intricate role of nutritional immunity in host immune cells of the lung and how changes in this fundamental process as a result of chronic lung disease may alter the airway microbiome, disease progression and the response to infection.https://doi.org/10.1186/s12931-021-01722-yNutritional immunityMicrobiomeImmunityMetalsIronCOPD |
| spellingShingle | Claire Healy Natalia Munoz-Wolf Janné Strydom Lynne Faherty Niamh C. Williams Sarah Kenny Seamas C. Donnelly Suzanne M. Cloonan Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease Respiratory Research Nutritional immunity Microbiome Immunity Metals Iron COPD |
| title | Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease |
| title_full | Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease |
| title_fullStr | Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease |
| title_full_unstemmed | Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease |
| title_short | Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease |
| title_sort | nutritional immunity the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease |
| topic | Nutritional immunity Microbiome Immunity Metals Iron COPD |
| url | https://doi.org/10.1186/s12931-021-01722-y |
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