Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran
Background: Transfusion-transmitted virus (TTV) is a single-stranded DNA virus. Renal transplant patients have a higher risk of TTV infection. Objective: To evaluate the prevalence of TTV and its correlation with post-renal transplantation complications in a population of Iranian patients. Methods...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-08-01
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| Series: | International Journal of Organ Transplantation Medicine |
| Subjects: | |
| Online Access: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/471 |
| _version_ | 1819002052421877760 |
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| author | H Akbari A Piroozmand E Dadgostar H Nikoueinejad Z Chitsazian B Einollahi J Amini Mahabadi |
| author_facet | H Akbari A Piroozmand E Dadgostar H Nikoueinejad Z Chitsazian B Einollahi J Amini Mahabadi |
| author_sort | H Akbari |
| collection | DOAJ |
| description | Background: Transfusion-transmitted virus (TTV) is a single-stranded DNA virus. Renal transplant patients have a higher risk of TTV infection.
Objective: To evaluate the prevalence of TTV and its correlation with post-renal transplantation complications in a population of Iranian patients.
Methods: A cross-sectional study was performed on 120 renal transplant recipients. TTV infection in the peripheral blood samples was detected by semi-nested polymerase chain reaction (semi-nested PCR). Then, the relationship between TTV and renal post-transplant complications was examined.
Results: 34.2% renal transplant recipients were positive for TTV. There was a significant correlation between the presence of TTV and diabetes, acute transplant rejection, and urinary tract infection. We did not find any direct correlation between the presence of TTV infection and hypertension, hyperlipidemia, respiratory tract infection, and cytomegalovirus infection.
Conclusion: We found an increased rate of TTV infection in renal transplant recipients associated with post-transplantation complications. TTV may be an important risk factor for some post-renal transplantation complications. |
| first_indexed | 2024-12-20T22:58:58Z |
| format | Article |
| id | doaj.art-9d43d1ab9c8247e9ae13f25cb77d6792 |
| institution | Directory Open Access Journal |
| issn | 2008-6482 2008-6490 |
| language | English |
| last_indexed | 2024-12-20T22:58:58Z |
| publishDate | 2018-08-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Organ Transplantation Medicine |
| spelling | doaj.art-9d43d1ab9c8247e9ae13f25cb77d67922022-12-21T19:24:03ZengShiraz University of Medical SciencesInternational Journal of Organ Transplantation Medicine2008-64822008-64902018-08-0193284Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in IranH Akbari0A Piroozmand1E Dadgostar2H Nikoueinejad3Z Chitsazian4B Einollahi5J Amini Mahabadi6Department of Biostatistics and Epidemiology, Kashan University of Medical Sciences, Kashan, IranDepartment of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran, and Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, IranStudent Research Committee, Kashan University of Medical Sciences, Kashan, IranNephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Kashan University of Medical Sciences, Kashan, IranNephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranGametogenesis Research center, Kashan University of Medical Sciences, Kashan, IranBackground: Transfusion-transmitted virus (TTV) is a single-stranded DNA virus. Renal transplant patients have a higher risk of TTV infection. Objective: To evaluate the prevalence of TTV and its correlation with post-renal transplantation complications in a population of Iranian patients. Methods: A cross-sectional study was performed on 120 renal transplant recipients. TTV infection in the peripheral blood samples was detected by semi-nested polymerase chain reaction (semi-nested PCR). Then, the relationship between TTV and renal post-transplant complications was examined. Results: 34.2% renal transplant recipients were positive for TTV. There was a significant correlation between the presence of TTV and diabetes, acute transplant rejection, and urinary tract infection. We did not find any direct correlation between the presence of TTV infection and hypertension, hyperlipidemia, respiratory tract infection, and cytomegalovirus infection. Conclusion: We found an increased rate of TTV infection in renal transplant recipients associated with post-transplantation complications. TTV may be an important risk factor for some post-renal transplantation complications.http://www.ijotm.com/ojs/index.php/IJOTM/article/view/471Renal transplantationTransfusion-transmitted virusPost-transplantation complications |
| spellingShingle | H Akbari A Piroozmand E Dadgostar H Nikoueinejad Z Chitsazian B Einollahi J Amini Mahabadi Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran International Journal of Organ Transplantation Medicine Renal transplantation Transfusion-transmitted virus Post-transplantation complications |
| title | Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran |
| title_full | Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran |
| title_fullStr | Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran |
| title_full_unstemmed | Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran |
| title_short | Prevalence of Transfusion-transmitted Virus (TTV) Infection and its Association with Renal Post-transplantation Complications in Iran |
| title_sort | prevalence of transfusion transmitted virus ttv infection and its association with renal post transplantation complications in iran |
| topic | Renal transplantation Transfusion-transmitted virus Post-transplantation complications |
| url | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/471 |
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