Effect of asciminib and vitamin K2 on Abelson tyrosine-kinase-inhibitor-resistant chronic myelogenous leukemia cells

Abstract Background Abelson (ABL) tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML); however, many patients develop resistance during ABL TKI therapy. Vitamin K2 (VK2) is a crucial fat-soluble vitamin used to activate hepatic coagulation factors and treat osteopo...

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Bibliographic Details
Main Authors: Seiichi Okabe, Akihiko Gotoh
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-023-11304-4