Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease
Background/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-11-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/368455 |
| _version_ | 1811206734347239424 |
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| author | Tao Peng Zhao Hu Ling Wu Dengren Li Xiangdong Yang |
| author_facet | Tao Peng Zhao Hu Ling Wu Dengren Li Xiangdong Yang |
| author_sort | Tao Peng |
| collection | DOAJ |
| description | Background/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present study. All patients in both groups had echocardiography examination. The concentration of endothelin-1, nitric oxide, and inducible nitric oxide synthase of serum of all patients and healthy volunteers was measured. The incidence of cardiac structural abnormalities in patients with chronic kidney disease, and the relationship between endothelial dysfunction and cardiac structural abnormalities were analyzed. Results: The incidence of left ventricular hypertrophy, left ventricular concentric remodeling, and left ventricular systolic dysfunction was 65%, 8.33%, and 16.67%, respectively. The level of endothelin-1 and nitric oxide increased in study-group, and the concentration of inducible nitric oxide synthase decreased. There was significant positively relationship between plasma endothelin-1 and left ventricular mass index, interventricular septal thickness, left ventricular diastolic diameter. There was negatively relationship between the level of serum nitric oxide and the maximum flow velocity at the mitral in left ventricular diastolic stage. There was not any correlation between inducible nitric oxide synthase with left ventricular remodeling. Conclusions: The results showed that there was a higher incidence of left ventricular hypertrophy in patients with chronic kidney disease. Endothelin-1 and nitric oxide played an important role on the development of left ventricular hypertrophy. i 2014 S. Karger AG, Basel |
| first_indexed | 2024-04-12T03:52:12Z |
| format | Article |
| id | doaj.art-9d448fd317b54415b4a65b558bd3402d |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-04-12T03:52:12Z |
| publishDate | 2014-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-9d448fd317b54415b4a65b558bd3402d2022-12-22T03:48:57ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432014-11-0139542042610.1159/000368455368455Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney DiseaseTao PengZhao HuLing WuDengren LiXiangdong YangBackground/Aims: To investigate the role of endothelial dysfunction on left ventricular remodeling in patients with chronic kidney disease and to evaluate the correlation between endothelial dysfunction and left ventricular remodeling. Methods: Seventy-three patients with chronic kidney disease as study-group and thirty healthy volunteers as control-group were enrolled in the present study. All patients in both groups had echocardiography examination. The concentration of endothelin-1, nitric oxide, and inducible nitric oxide synthase of serum of all patients and healthy volunteers was measured. The incidence of cardiac structural abnormalities in patients with chronic kidney disease, and the relationship between endothelial dysfunction and cardiac structural abnormalities were analyzed. Results: The incidence of left ventricular hypertrophy, left ventricular concentric remodeling, and left ventricular systolic dysfunction was 65%, 8.33%, and 16.67%, respectively. The level of endothelin-1 and nitric oxide increased in study-group, and the concentration of inducible nitric oxide synthase decreased. There was significant positively relationship between plasma endothelin-1 and left ventricular mass index, interventricular septal thickness, left ventricular diastolic diameter. There was negatively relationship between the level of serum nitric oxide and the maximum flow velocity at the mitral in left ventricular diastolic stage. There was not any correlation between inducible nitric oxide synthase with left ventricular remodeling. Conclusions: The results showed that there was a higher incidence of left ventricular hypertrophy in patients with chronic kidney disease. Endothelin-1 and nitric oxide played an important role on the development of left ventricular hypertrophy. i 2014 S. Karger AG, Baselhttp://www.karger.com/Article/FullText/368455Endothelin-1Nitric oxideInducible nitric oxide synthaseVentricular remodelingChronic kidney disease |
| spellingShingle | Tao Peng Zhao Hu Ling Wu Dengren Li Xiangdong Yang Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease Kidney & Blood Pressure Research Endothelin-1 Nitric oxide Inducible nitric oxide synthase Ventricular remodeling Chronic kidney disease |
| title | Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease |
| title_full | Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease |
| title_fullStr | Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease |
| title_full_unstemmed | Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease |
| title_short | Correlation Between Endothelial Dysfunction and Left Ventricular Remodeling in Patients with Chronic Kidney Disease |
| title_sort | correlation between endothelial dysfunction and left ventricular remodeling in patients with chronic kidney disease |
| topic | Endothelin-1 Nitric oxide Inducible nitric oxide synthase Ventricular remodeling Chronic kidney disease |
| url | http://www.karger.com/Article/FullText/368455 |
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