Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes

Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes

Prion diseases arise from the conformational conversion of the cellular prion protein (PrP<sup>C</sup>) into a self-replicating prion isoform (PrP<sup>Sc</sup>). Although this process has been studied mostly in neurons, a growing body of evidence suggests that astrocytes expr...

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Bibliographic Details
Main Authors: Giulia Dematteis, Elena Restelli, Virginia Vita Vanella, Marcello Manfredi, Emilio Marengo, Marco Corazzari, Armando A. Genazzani, Roberto Chiesa, Dmitry Lim, Laura Tapella
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
astrocytes
calcineurin
FK506
prion protein
protein synthesis
calcium
Online Access:https://www.mdpi.com/2073-4409/11/4/609

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