Mitochondrial Dysfunction in the Transition from NASH to HCC

The liver constantly adapts to meet energy requirements of the whole body. Despite its remarkable adaptative capacity, prolonged exposure of liver cells to harmful environmental cues (such as diets rich in fat, sugar, and cholesterol) results in the development of chronic liver diseases (including n...

Full description

Bibliographic Details
Main Authors: Mélissa Léveillé, Jennifer L. Estall
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/9/10/233
_version_ 1819213426921046016
author Mélissa Léveillé
Jennifer L. Estall
author_facet Mélissa Léveillé
Jennifer L. Estall
author_sort Mélissa Léveillé
collection DOAJ
description The liver constantly adapts to meet energy requirements of the whole body. Despite its remarkable adaptative capacity, prolonged exposure of liver cells to harmful environmental cues (such as diets rich in fat, sugar, and cholesterol) results in the development of chronic liver diseases (including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)) that can progress to hepatocellular carcinoma (HCC). The pathogenesis of these diseases is extremely complex, multifactorial, and poorly understood. Emerging evidence suggests that mitochondrial dysfunction or maladaptation contributes to detrimental effects on hepatocyte bioenergetics, reactive oxygen species (ROS) homeostasis, endoplasmic reticulum (ER) stress, inflammation, and cell death leading to NASH and HCC. The present review highlights the potential contribution of altered mitochondria function to NASH-related HCC and discusses how agents targeting this organelle could provide interesting treatment strategies for these diseases.
first_indexed 2024-12-23T06:58:41Z
format Article
id doaj.art-9d4529c048344d7d9a4d14e640fc13e8
institution Directory Open Access Journal
issn 2218-1989
language English
last_indexed 2024-12-23T06:58:41Z
publishDate 2019-10-01
publisher MDPI AG
record_format Article
series Metabolites
spelling doaj.art-9d4529c048344d7d9a4d14e640fc13e82022-12-21T17:56:14ZengMDPI AGMetabolites2218-19892019-10-0191023310.3390/metabo9100233metabo9100233Mitochondrial Dysfunction in the Transition from NASH to HCCMélissa Léveillé0Jennifer L. Estall1Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, QC H2W 1R7, CanadaInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, QC H2W 1R7, CanadaThe liver constantly adapts to meet energy requirements of the whole body. Despite its remarkable adaptative capacity, prolonged exposure of liver cells to harmful environmental cues (such as diets rich in fat, sugar, and cholesterol) results in the development of chronic liver diseases (including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)) that can progress to hepatocellular carcinoma (HCC). The pathogenesis of these diseases is extremely complex, multifactorial, and poorly understood. Emerging evidence suggests that mitochondrial dysfunction or maladaptation contributes to detrimental effects on hepatocyte bioenergetics, reactive oxygen species (ROS) homeostasis, endoplasmic reticulum (ER) stress, inflammation, and cell death leading to NASH and HCC. The present review highlights the potential contribution of altered mitochondria function to NASH-related HCC and discusses how agents targeting this organelle could provide interesting treatment strategies for these diseases.https://www.mdpi.com/2218-1989/9/10/233mitochondriametabolismlivernafldnashhcc
spellingShingle Mélissa Léveillé
Jennifer L. Estall
Mitochondrial Dysfunction in the Transition from NASH to HCC
Metabolites
mitochondria
metabolism
liver
nafld
nash
hcc
title Mitochondrial Dysfunction in the Transition from NASH to HCC
title_full Mitochondrial Dysfunction in the Transition from NASH to HCC
title_fullStr Mitochondrial Dysfunction in the Transition from NASH to HCC
title_full_unstemmed Mitochondrial Dysfunction in the Transition from NASH to HCC
title_short Mitochondrial Dysfunction in the Transition from NASH to HCC
title_sort mitochondrial dysfunction in the transition from nash to hcc
topic mitochondria
metabolism
liver
nafld
nash
hcc
url https://www.mdpi.com/2218-1989/9/10/233
work_keys_str_mv AT melissaleveille mitochondrialdysfunctioninthetransitionfromnashtohcc
AT jenniferlestall mitochondrialdysfunctioninthetransitionfromnashtohcc