Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens
Carbon monoxide (CO) has long been known for its toxicity. However, in recent decades, new applications for CO as a therapeutic compound have been proposed, and multiple forms of CO therapy have since been developed and studied. Previous research has found that CO has a role as a gasotransmitter and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Chemistry |
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| Online Access: | https://www.mdpi.com/2624-8549/3/3/57 |
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| author | Flavia Cavicchioli Izzy M. Cesarotti Madison Fangman Josh Lua Raymond Hautamaki Sylvain Doré |
| author_facet | Flavia Cavicchioli Izzy M. Cesarotti Madison Fangman Josh Lua Raymond Hautamaki Sylvain Doré |
| author_sort | Flavia Cavicchioli |
| collection | DOAJ |
| description | Carbon monoxide (CO) has long been known for its toxicity. However, in recent decades, new applications for CO as a therapeutic compound have been proposed, and multiple forms of CO therapy have since been developed and studied. Previous research has found that CO has a role as a gasotransmitter and promotes anti-inflammatory and antioxidant effects, making it an avenue of interest for medicine. Such effects are possible because of the Nrf2/HO1 pathway, which has become a target for therapy development because its activation also leads to CO release. Currently, different forms of treatment involving CO include inhaled CO (iCO), carbon monoxide-releasing molecules (CORMs), and hybrid carbon monoxide-releasing molecules (HYCOs). In this article, we review the progression of CO studies to develop possible therapies, the possible mechanisms involved in the effects of CO, and the current forms of therapy using CO. |
| first_indexed | 2024-03-10T07:48:36Z |
| format | Article |
| id | doaj.art-9d477c3ed2d54eac936e263a1c390142 |
| institution | Directory Open Access Journal |
| issn | 2624-8549 |
| language | English |
| last_indexed | 2024-03-10T07:48:36Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry |
| spelling | doaj.art-9d477c3ed2d54eac936e263a1c3901422023-11-22T12:28:05ZengMDPI AGChemistry2624-85492021-07-013380081710.3390/chemistry3030057Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective LensFlavia Cavicchioli0Izzy M. Cesarotti1Madison Fangman2Josh Lua3Raymond Hautamaki4Sylvain Doré5Center for Translational Research in Neurodegenerative Disease, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USACenter for Translational Research in Neurodegenerative Disease, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USACenter for Translational Research in Neurodegenerative Disease, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USACenter for Translational Research in Neurodegenerative Disease, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USACenter for Translational Research in Neurodegenerative Disease, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USACenter for Translational Research in Neurodegenerative Disease, Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, USACarbon monoxide (CO) has long been known for its toxicity. However, in recent decades, new applications for CO as a therapeutic compound have been proposed, and multiple forms of CO therapy have since been developed and studied. Previous research has found that CO has a role as a gasotransmitter and promotes anti-inflammatory and antioxidant effects, making it an avenue of interest for medicine. Such effects are possible because of the Nrf2/HO1 pathway, which has become a target for therapy development because its activation also leads to CO release. Currently, different forms of treatment involving CO include inhaled CO (iCO), carbon monoxide-releasing molecules (CORMs), and hybrid carbon monoxide-releasing molecules (HYCOs). In this article, we review the progression of CO studies to develop possible therapies, the possible mechanisms involved in the effects of CO, and the current forms of therapy using CO.https://www.mdpi.com/2624-8549/3/3/57CORMgasotransmittersCO (carbon monoxide)Nrf2HYCO (hybrid CORMs)heme oxygenase-1 |
| spellingShingle | Flavia Cavicchioli Izzy M. Cesarotti Madison Fangman Josh Lua Raymond Hautamaki Sylvain Doré Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens Chemistry CORM gasotransmitters CO (carbon monoxide) Nrf2 HYCO (hybrid CORMs) heme oxygenase-1 |
| title | Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens |
| title_full | Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens |
| title_fullStr | Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens |
| title_full_unstemmed | Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens |
| title_short | Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens |
| title_sort | carbon monoxide therapy using hybrid carbon monoxide releasing nrf2 inducing molecules through a neuroprotective lens |
| topic | CORM gasotransmitters CO (carbon monoxide) Nrf2 HYCO (hybrid CORMs) heme oxygenase-1 |
| url | https://www.mdpi.com/2624-8549/3/3/57 |
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