High myopia at high altitudes
Background: Optic nerve sheath diameter (ONSD) increases significantly at high altitudes, and is associated with the presence and severity of acute mountain sickness (AMS). Exposure to hypobaria, hypoxia, and coldness when hiking also impacts intraocular pressure (IOP). To date, little is known abou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1350051/full |
| _version_ | 1797269057318158336 |
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| author | Ta-Wei Wang Ming-Kun Huang Ming-Kun Huang Ming-Kun Huang Chih-Chun Hsu Szu-Yang Jo Yen-Kuang Lin Chorng-Kuang How Chorng-Kuang How Shih-Fen Tseng Kong Chung Ding-Kuo Chien Ding-Kuo Chien Wen-Han Chang Wen-Han Chang Yu-Hui Chiu Yu-Hui Chiu Yu-Hui Chiu |
| author_facet | Ta-Wei Wang Ming-Kun Huang Ming-Kun Huang Ming-Kun Huang Chih-Chun Hsu Szu-Yang Jo Yen-Kuang Lin Chorng-Kuang How Chorng-Kuang How Shih-Fen Tseng Kong Chung Ding-Kuo Chien Ding-Kuo Chien Wen-Han Chang Wen-Han Chang Yu-Hui Chiu Yu-Hui Chiu Yu-Hui Chiu |
| author_sort | Ta-Wei Wang |
| collection | DOAJ |
| description | Background: Optic nerve sheath diameter (ONSD) increases significantly at high altitudes, and is associated with the presence and severity of acute mountain sickness (AMS). Exposure to hypobaria, hypoxia, and coldness when hiking also impacts intraocular pressure (IOP). To date, little is known about ocular physiological responses in trekkers with myopia at high altitudes. This study aimed to determine changes in the ONSD and IOP between participants with and without high myopia (HM) during hiking and to test whether these changes could predict symptoms of AMS.Methods: Nine participants with HM and 18 without HM participated in a 3-day trek of Xue Mountain. The ONSD, IOP, and questionnaires were examined before and during the trek of Xue Mountain.Results: The ONSD values increased significantly in both HM (p = 0.005) and non-HM trekkers (p = 0.018) at an altitude of 1,700 m. In the HM group, IOP levels were greater than those in the non-HM group (p = 0.034) on the first day of trekking (altitude: 3,150 m). No statistically significant difference was observed between the two groups for the values of ONSD. Fractional changes in ONSD at an altitude of 1,700 m were related to the development of AMS (rpb = 0.448, p = 0.019) and the presence of headache symptoms (rpb = 0.542, p = 0.004). The area under the ROC curve for the diagnostic performance of ONSD fractional changes at an altitude of 1,700 m was 0.859 for predicting the development of AMS and 0.803 for predicting the presence of headache symptoms.Conclusion: Analysis of changes in ONSD at moderate altitude could predict AMS symptoms before an ascent to high altitude. Myopia may impact physiological accommodation at high altitudes, and HM trekkers potentially demonstrate suboptimal regulation of aqueous humor in such environments. |
| first_indexed | 2024-04-25T01:42:19Z |
| format | Article |
| id | doaj.art-9d49effbf5f243f2945ca98e52aec214 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-25T01:42:19Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-9d49effbf5f243f2945ca98e52aec2142024-03-08T04:46:42ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-03-011510.3389/fphys.2024.13500511350051High myopia at high altitudesTa-Wei Wang0Ming-Kun Huang1Ming-Kun Huang2Ming-Kun Huang3Chih-Chun Hsu4Szu-Yang Jo5Yen-Kuang Lin6Chorng-Kuang How7Chorng-Kuang How8Shih-Fen Tseng9Kong Chung10Ding-Kuo Chien11Ding-Kuo Chien12Wen-Han Chang13Wen-Han Chang14Yu-Hui Chiu15Yu-Hui Chiu16Yu-Hui Chiu17Department of Emergency Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDepartment of Emergency Medicine, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Electronic Engineering, National Taipei University of Technology, Taipei, TaiwanDepartment of Emergency, Hsinchu MacKay Memorial Hospital, Hsinchu, TaiwanDepartment of Emergency Medicine, MacKay Memorial Hospital, Taipei, TaiwanGraduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan, TaiwanDepartment of Emergency Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Emergency Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Emergency Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDepartment of Emergency Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, TaiwanDepartment of Emergency Medicine, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Emergency Medicine, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Emergency Medicine, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanBackground: Optic nerve sheath diameter (ONSD) increases significantly at high altitudes, and is associated with the presence and severity of acute mountain sickness (AMS). Exposure to hypobaria, hypoxia, and coldness when hiking also impacts intraocular pressure (IOP). To date, little is known about ocular physiological responses in trekkers with myopia at high altitudes. This study aimed to determine changes in the ONSD and IOP between participants with and without high myopia (HM) during hiking and to test whether these changes could predict symptoms of AMS.Methods: Nine participants with HM and 18 without HM participated in a 3-day trek of Xue Mountain. The ONSD, IOP, and questionnaires were examined before and during the trek of Xue Mountain.Results: The ONSD values increased significantly in both HM (p = 0.005) and non-HM trekkers (p = 0.018) at an altitude of 1,700 m. In the HM group, IOP levels were greater than those in the non-HM group (p = 0.034) on the first day of trekking (altitude: 3,150 m). No statistically significant difference was observed between the two groups for the values of ONSD. Fractional changes in ONSD at an altitude of 1,700 m were related to the development of AMS (rpb = 0.448, p = 0.019) and the presence of headache symptoms (rpb = 0.542, p = 0.004). The area under the ROC curve for the diagnostic performance of ONSD fractional changes at an altitude of 1,700 m was 0.859 for predicting the development of AMS and 0.803 for predicting the presence of headache symptoms.Conclusion: Analysis of changes in ONSD at moderate altitude could predict AMS symptoms before an ascent to high altitude. Myopia may impact physiological accommodation at high altitudes, and HM trekkers potentially demonstrate suboptimal regulation of aqueous humor in such environments.https://www.frontiersin.org/articles/10.3389/fphys.2024.1350051/fullhigh myopiahigh altitudesacute mountain sicknessintraocular pressureoptic nerve sheath diameter |
| spellingShingle | Ta-Wei Wang Ming-Kun Huang Ming-Kun Huang Ming-Kun Huang Chih-Chun Hsu Szu-Yang Jo Yen-Kuang Lin Chorng-Kuang How Chorng-Kuang How Shih-Fen Tseng Kong Chung Ding-Kuo Chien Ding-Kuo Chien Wen-Han Chang Wen-Han Chang Yu-Hui Chiu Yu-Hui Chiu Yu-Hui Chiu High myopia at high altitudes Frontiers in Physiology high myopia high altitudes acute mountain sickness intraocular pressure optic nerve sheath diameter |
| title | High myopia at high altitudes |
| title_full | High myopia at high altitudes |
| title_fullStr | High myopia at high altitudes |
| title_full_unstemmed | High myopia at high altitudes |
| title_short | High myopia at high altitudes |
| title_sort | high myopia at high altitudes |
| topic | high myopia high altitudes acute mountain sickness intraocular pressure optic nerve sheath diameter |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1350051/full |
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