Urinary protein carbonyl levels and its correlation with protein misfolding in preeclampsia
Objective: To evaluate the association of protein carbonylation with preeclampsia and its correlation with urinary protein misfolding.Method: Protein carbonyl and misfolded protein levels were measured in the midstream urine sample (58 preeclamptic and 44 normotensive pregnancy) by ELISA and Congo R...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2019.1590720 |
| Summary: | Objective: To evaluate the association of protein carbonylation with preeclampsia and its correlation with urinary protein misfolding.Method: Protein carbonyl and misfolded protein levels were measured in the midstream urine sample (58 preeclamptic and 44 normotensive pregnancy) by ELISA and Congo Red Dot assay respectively.Results: Significant difference was observed in the levels of protein carbonyls (P = 0.002) and misfolded proteins (P = 0.001). Correlation between protein carbonyl and misfolded proteins levels was significant but weak (r = 0.3; P = 0.018).Conclusion: Urinary protein carbonyl level is elevated in preeclampsia but plays a minor role in proteins misfolding. |
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| ISSN: | 1064-1955 1525-6065 |