Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota
The gut microbiota has been linked to blood lipids. However, the relationship between the gut microbiome and other lipid markers like apolipoproteins A1 (apoA1) and B (apoB) as well as classical lipid markers in Asians remain unclear. Here, we examined the associations between gut microbial diversit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/5/1589 |
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| author | Kyung Eun Yun Jimin Kim Mi-hyun Kim Eunkyo Park Hyung-Lae Kim Yoosoo Chang Seungho Ryu Han-Na Kim |
| author_facet | Kyung Eun Yun Jimin Kim Mi-hyun Kim Eunkyo Park Hyung-Lae Kim Yoosoo Chang Seungho Ryu Han-Na Kim |
| author_sort | Kyung Eun Yun |
| collection | DOAJ |
| description | The gut microbiota has been linked to blood lipids. However, the relationship between the gut microbiome and other lipid markers like apolipoproteins A1 (apoA1) and B (apoB) as well as classical lipid markers in Asians remain unclear. Here, we examined the associations between gut microbial diversity and taxonomic compositions with both apolipoproteins and lipid markers in a large number of Korean patients. The fecal 16S rRNA gene sequencing data from 1141 subjects were analyzed and subjects were categorized into control group (G0) or abnormal group (G1) according to blood lipid measurements. The microbial diversity and several taxa of the gut microbiota were significantly associated with triglyceride, apoA1, and apoB levels, but not with total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels. The alpha diversity of the gut microbiota was inversely associated with high triglyceride level. Interestingly, G1 of apoA1 showed increased microbial richness and distinct microbial community compared with G0 of apoA1. A high abundance of Fusobacteria and low abundance of <i>Oscillospira</i> were found in the hypertriglyceridemia group. In this large-scale study, we identified associations of gut microbiota with apolipoproteins and classical lipid markers, indicating that the gut microbiota may be an important target for regulating blood lipids. |
| first_indexed | 2024-03-10T19:37:52Z |
| format | Article |
| id | doaj.art-9d4b271347fa49c4ac680afb56d69d6d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:37:52Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9d4b271347fa49c4ac680afb56d69d6d2023-11-20T01:31:33ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0195158910.3390/jcm9051589Major Lipids, Apolipoproteins, and Alterations of Gut MicrobiotaKyung Eun Yun0Jimin Kim1Mi-hyun Kim2Eunkyo Park3Hyung-Lae Kim4Yoosoo Chang5Seungho Ryu6Han-Na Kim7Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, KoreaCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, KoreaCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, KoreaDepartment of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, KoreaDepartment of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, KoreaCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, KoreaCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, KoreaCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, KoreaThe gut microbiota has been linked to blood lipids. However, the relationship between the gut microbiome and other lipid markers like apolipoproteins A1 (apoA1) and B (apoB) as well as classical lipid markers in Asians remain unclear. Here, we examined the associations between gut microbial diversity and taxonomic compositions with both apolipoproteins and lipid markers in a large number of Korean patients. The fecal 16S rRNA gene sequencing data from 1141 subjects were analyzed and subjects were categorized into control group (G0) or abnormal group (G1) according to blood lipid measurements. The microbial diversity and several taxa of the gut microbiota were significantly associated with triglyceride, apoA1, and apoB levels, but not with total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels. The alpha diversity of the gut microbiota was inversely associated with high triglyceride level. Interestingly, G1 of apoA1 showed increased microbial richness and distinct microbial community compared with G0 of apoA1. A high abundance of Fusobacteria and low abundance of <i>Oscillospira</i> were found in the hypertriglyceridemia group. In this large-scale study, we identified associations of gut microbiota with apolipoproteins and classical lipid markers, indicating that the gut microbiota may be an important target for regulating blood lipids.https://www.mdpi.com/2077-0383/9/5/1589gut microbiotablood lipidtriglycerideapolipoprotein16S rRNA |
| spellingShingle | Kyung Eun Yun Jimin Kim Mi-hyun Kim Eunkyo Park Hyung-Lae Kim Yoosoo Chang Seungho Ryu Han-Na Kim Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota Journal of Clinical Medicine gut microbiota blood lipid triglyceride apolipoprotein 16S rRNA |
| title | Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota |
| title_full | Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota |
| title_fullStr | Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota |
| title_full_unstemmed | Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota |
| title_short | Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota |
| title_sort | major lipids apolipoproteins and alterations of gut microbiota |
| topic | gut microbiota blood lipid triglyceride apolipoprotein 16S rRNA |
| url | https://www.mdpi.com/2077-0383/9/5/1589 |
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