“T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach”
<p>Abstract</p> <p>T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alpha/delta), 14q32 (TCL1)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-08-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | http://www.ehoonline.org/content/1/1/21 |
| _version_ | 1818229142974365696 |
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| author | Tirado Carlos A Starshak Phillip Delgado Paul Rao Nagesh |
| author_facet | Tirado Carlos A Starshak Phillip Delgado Paul Rao Nagesh |
| author_sort | Tirado Carlos A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alpha/delta), 14q32 (TCL1) or Xq28 (MTCP-1), abnormalities of chromosome 8, 12p and deletions of the long arm of chromosomes 5, 6, 11 and 13. Cytogenetics, FISH, comparative genomic hybridization (CGH) , SNP arrays with high resolution analysis have provided more precisely frequent submicroscopic gene and genomic lesions as well as breakpoints involved in the pathogenesis of this disease. One of the cornerstones to diagnose T-PLL are cytogenetic analysis. Here we summarize the current cytogenetic findings and we also describe two distinct cases of T-PLL where cytogenetics, FISH , morphologic analysis and flow cytometry helped to diagnose them accurately.</p> |
| first_indexed | 2024-12-12T10:13:54Z |
| format | Article |
| id | doaj.art-9d4c3d855afb4daeba90f63b9f181403 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-12T10:13:54Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-9d4c3d855afb4daeba90f63b9f1814032022-12-22T00:27:43ZengBMCExperimental Hematology & Oncology2162-36192012-08-01112110.1186/2162-3619-1-21“T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach”Tirado Carlos AStarshak PhillipDelgado PaulRao Nagesh<p>Abstract</p> <p>T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alpha/delta), 14q32 (TCL1) or Xq28 (MTCP-1), abnormalities of chromosome 8, 12p and deletions of the long arm of chromosomes 5, 6, 11 and 13. Cytogenetics, FISH, comparative genomic hybridization (CGH) , SNP arrays with high resolution analysis have provided more precisely frequent submicroscopic gene and genomic lesions as well as breakpoints involved in the pathogenesis of this disease. One of the cornerstones to diagnose T-PLL are cytogenetic analysis. Here we summarize the current cytogenetic findings and we also describe two distinct cases of T-PLL where cytogenetics, FISH , morphologic analysis and flow cytometry helped to diagnose them accurately.</p>http://www.ehoonline.org/content/1/1/21T-PLLCytogeneticsFISH |
| spellingShingle | Tirado Carlos A Starshak Phillip Delgado Paul Rao Nagesh “T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach” Experimental Hematology & Oncology T-PLL Cytogenetics FISH |
| title | “T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach” |
| title_full | “T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach” |
| title_fullStr | “T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach” |
| title_full_unstemmed | “T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach” |
| title_short | “T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach” |
| title_sort | t cell prolymphocytic leukemia t pll a heterogeneous disease exemplified by two cases and the important role of cytogenetics a multidisciplinary approach |
| topic | T-PLL Cytogenetics FISH |
| url | http://www.ehoonline.org/content/1/1/21 |
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