Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment
Poly(D,L,-lactide-<i>co</i>-glycolide) (PLGA) foam samples impregnated with rutin were successfully produced by supercritical foaming processes. A number of parameters such as pressure (80–200 bar), temperature (35–55 °C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/10/1645 |
| _version_ | 1797533561503350784 |
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| author | Diego Valor Antonio Montes Marilia Monteiro Ignacio García-Casas Clara Pereyra Enrique Martínez de la Ossa |
| author_facet | Diego Valor Antonio Montes Marilia Monteiro Ignacio García-Casas Clara Pereyra Enrique Martínez de la Ossa |
| author_sort | Diego Valor |
| collection | DOAJ |
| description | Poly(D,L,-lactide-<i>co</i>-glycolide) (PLGA) foam samples impregnated with rutin were successfully produced by supercritical foaming processes. A number of parameters such as pressure (80–200 bar), temperature (35–55 °C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of the poly(D,L,-lactide-<i>co</i>-glycolide) (50:50 and 75:25) were studied to determine their effect on the expansion factor and on the glass transition temperature of the polymer foams and their consequences on the release profile of the rutin entrapped in them. The impregnated foams were characterized by scanning electron microscopy, differential scanning calorimetry, and mercury intrusion porosimetry. A greater impregnation of rutin into the polymer foam pores was observed as pressure was increased. The release of rutin in a phosphate buffer solution was investigated. The controlled release tests confirmed that the modification of certain variables would result in considerable differences in the drug release profiles. Thus, five-day drug release periods were achieved under high pressure and temperature while the depressurization rate remained low. |
| first_indexed | 2024-03-10T11:17:17Z |
| format | Article |
| id | doaj.art-9d4d23957790488f95b39a1cb6d85653 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T11:17:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-9d4d23957790488f95b39a1cb6d856532023-11-21T20:20:55ZengMDPI AGPolymers2073-43602021-05-011310164510.3390/polym13101645Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical TreatmentDiego Valor0Antonio Montes1Marilia Monteiro2Ignacio García-Casas3Clara Pereyra4Enrique Martínez de la Ossa5Department of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, International Excellence Agrifood Campus (CeiA3), Campus Universitario Río San Pedro, 11510 Puerto Real, SpainDepartment of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, International Excellence Agrifood Campus (CeiA3), Campus Universitario Río San Pedro, 11510 Puerto Real, SpainTechnische Hochschule Nürnberg, Fakultät Verfahrenstechnik, Wassertorstr. 10, 90489 Nuremberg, GermanyDepartment of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, International Excellence Agrifood Campus (CeiA3), Campus Universitario Río San Pedro, 11510 Puerto Real, SpainDepartment of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, International Excellence Agrifood Campus (CeiA3), Campus Universitario Río San Pedro, 11510 Puerto Real, SpainDepartment of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, International Excellence Agrifood Campus (CeiA3), Campus Universitario Río San Pedro, 11510 Puerto Real, SpainPoly(D,L,-lactide-<i>co</i>-glycolide) (PLGA) foam samples impregnated with rutin were successfully produced by supercritical foaming processes. A number of parameters such as pressure (80–200 bar), temperature (35–55 °C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of the poly(D,L,-lactide-<i>co</i>-glycolide) (50:50 and 75:25) were studied to determine their effect on the expansion factor and on the glass transition temperature of the polymer foams and their consequences on the release profile of the rutin entrapped in them. The impregnated foams were characterized by scanning electron microscopy, differential scanning calorimetry, and mercury intrusion porosimetry. A greater impregnation of rutin into the polymer foam pores was observed as pressure was increased. The release of rutin in a phosphate buffer solution was investigated. The controlled release tests confirmed that the modification of certain variables would result in considerable differences in the drug release profiles. Thus, five-day drug release periods were achieved under high pressure and temperature while the depressurization rate remained low.https://www.mdpi.com/2073-4360/13/10/1645PLGAsupercritical CO<sub>2</sub> foamingrutinscaffoldsrelease profile |
| spellingShingle | Diego Valor Antonio Montes Marilia Monteiro Ignacio García-Casas Clara Pereyra Enrique Martínez de la Ossa Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment Polymers PLGA supercritical CO<sub>2</sub> foaming rutin scaffolds release profile |
| title | Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment |
| title_full | Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment |
| title_fullStr | Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment |
| title_full_unstemmed | Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment |
| title_short | Determining the Optimal Conditions for the Production by Supercritical CO<sub>2</sub> of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment |
| title_sort | determining the optimal conditions for the production by supercritical co sub 2 sub of biodegradable plga foams for the controlled release of rutin as a medical treatment |
| topic | PLGA supercritical CO<sub>2</sub> foaming rutin scaffolds release profile |
| url | https://www.mdpi.com/2073-4360/13/10/1645 |
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