Deletion of Glutamine Synthetase Gene Disrupts the Survivability and Infectivity of Leishmania donovani

Deletion of Glutamine Synthetase Gene Disrupts the Survivability and Infectivity of Leishmania donovani

Glutamine synthetase (GS) is one of the most important metabolic enzymes which catalyzes ligation of glutamate and ammonia to form glutamine. Previous studies from our lab had revealed significant differences in parasite and host GS enzyme which warranted us to further work on its relevance in paras...

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Bibliographic Details
Main Authors: Vinay Kumar, Sanhita Ghosh, Kamalika Roy, Chiranjib Pal, Sushma Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
leishmaniasis
glutamine synthetase
knockout
essentiality
infectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.622266/full

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