National prevalence of IC/BPS in women and men utilizing veterans health administration data
ImportanceInterstitial cystitis/bladder pain syndrome (IC/BPS) is an immense burden to both patients and the American healthcare system; it is notoriously difficult to diagnose. Prevalence estimates vary widely (150-fold range in women and >500-fold range in men).ObjectivesWe aimed to create...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2022.925834/full |
| _version_ | 1818496308567080960 |
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| author | Jennifer T. Anger Kai B. Dallas Catherine Bresee Amanda M. De Hoedt Kamil E. Barbour Katherine J. Hoggatt Marc T. Goodman Jayoung Kim Jayoung Kim Stephen J. Freedland Stephen J. Freedland Stephen J. Freedland |
| author_facet | Jennifer T. Anger Kai B. Dallas Catherine Bresee Amanda M. De Hoedt Kamil E. Barbour Katherine J. Hoggatt Marc T. Goodman Jayoung Kim Jayoung Kim Stephen J. Freedland Stephen J. Freedland Stephen J. Freedland |
| author_sort | Jennifer T. Anger |
| collection | DOAJ |
| description | ImportanceInterstitial cystitis/bladder pain syndrome (IC/BPS) is an immense burden to both patients and the American healthcare system; it is notoriously difficult to diagnose. Prevalence estimates vary widely (150-fold range in women and >500-fold range in men).ObjectivesWe aimed to create accurate national IC/BPS prevalence estimates by employing a novel methodology combining a national population-based dataset with individual chart abstraction.Study designIn this epidemiological survey, all living patients, with ≥2 clinic visits from 2016 to 2018 in the Veterans Health Administration, with an ICD-9/10 code for IC/BPS (n = 9,503) or similar conditions that may represent undiagnosed IC/BPS (n = 124,331), were identified (other were controls n = 5,069,695). A detailed chart review of random gender-balanced samples confirmed the true presence of IC/PBS, which were then age- and gender-matched to the general US population.ResultsOf the 5,203,529 patients identified, IC/BPS was confirmed in 541 of 1,647 sampled charts with an IC/BPS ICD code, 10 of 382 charts with an ICD-like code, and 3 of 916 controls. After age- and gender-matching to the general US population, this translated to national prevalence estimates of 0.87% (95% CI: 0.32, 1.42), with female and male prevalence of 1.08% (95% CI: 0.03, 2.13) and 0.66% (95% CI: 0.44, 0.87), respectively.ConclusionsWe estimate the prevalence of IC/BPS to be 0.87%, which is lower than prior estimates based on survey data, but higher than prior estimates based on administrative data. These potentially represent the most accurate estimates to date, given the broader and more heterogeneous population studied and our novel methodology of combining in-depth chart abstraction with administrative data. |
| first_indexed | 2024-12-10T18:31:43Z |
| format | Article |
| id | doaj.art-9d5175f5abaf4654a486fdc7321304b9 |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-12-10T18:31:43Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-9d5175f5abaf4654a486fdc7321304b92022-12-22T01:37:56ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2022-08-01310.3389/fpain.2022.925834925834National prevalence of IC/BPS in women and men utilizing veterans health administration dataJennifer T. Anger0Kai B. Dallas1Catherine Bresee2Amanda M. De Hoedt3Kamil E. Barbour4Katherine J. Hoggatt5Marc T. Goodman6Jayoung Kim7Jayoung Kim8Stephen J. Freedland9Stephen J. Freedland10Stephen J. Freedland11Department of Urology, UC San Diego Health, San Diego, CA, United StatesCity of Hope Urology, Duarte, CA, United StatesDepartment of Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesUrology Section, Department of Surgery, Veterans Affairs Medical Centers Division of Population Health, Durham, NC, United StatesNational Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United StatesCenter for Study of Healthcare Implementation, Innovation and Policy Veterans Health Administration, Los Angeles, CA, United StatesCedars-Sinai Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCedars-Sinai Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Surgery and Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesUrology Section, Department of Surgery, Veterans Affairs Medical Centers Division of Population Health, Durham, NC, United StatesCedars-Sinai Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesDepartment of Surgery and Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesImportanceInterstitial cystitis/bladder pain syndrome (IC/BPS) is an immense burden to both patients and the American healthcare system; it is notoriously difficult to diagnose. Prevalence estimates vary widely (150-fold range in women and >500-fold range in men).ObjectivesWe aimed to create accurate national IC/BPS prevalence estimates by employing a novel methodology combining a national population-based dataset with individual chart abstraction.Study designIn this epidemiological survey, all living patients, with ≥2 clinic visits from 2016 to 2018 in the Veterans Health Administration, with an ICD-9/10 code for IC/BPS (n = 9,503) or similar conditions that may represent undiagnosed IC/BPS (n = 124,331), were identified (other were controls n = 5,069,695). A detailed chart review of random gender-balanced samples confirmed the true presence of IC/PBS, which were then age- and gender-matched to the general US population.ResultsOf the 5,203,529 patients identified, IC/BPS was confirmed in 541 of 1,647 sampled charts with an IC/BPS ICD code, 10 of 382 charts with an ICD-like code, and 3 of 916 controls. After age- and gender-matching to the general US population, this translated to national prevalence estimates of 0.87% (95% CI: 0.32, 1.42), with female and male prevalence of 1.08% (95% CI: 0.03, 2.13) and 0.66% (95% CI: 0.44, 0.87), respectively.ConclusionsWe estimate the prevalence of IC/BPS to be 0.87%, which is lower than prior estimates based on survey data, but higher than prior estimates based on administrative data. These potentially represent the most accurate estimates to date, given the broader and more heterogeneous population studied and our novel methodology of combining in-depth chart abstraction with administrative data.https://www.frontiersin.org/articles/10.3389/fpain.2022.925834/fullinterstitial cystitisbladder pain syndromeIC/BPSepidemiologyprevalencesex/gender |
| spellingShingle | Jennifer T. Anger Kai B. Dallas Catherine Bresee Amanda M. De Hoedt Kamil E. Barbour Katherine J. Hoggatt Marc T. Goodman Jayoung Kim Jayoung Kim Stephen J. Freedland Stephen J. Freedland Stephen J. Freedland National prevalence of IC/BPS in women and men utilizing veterans health administration data Frontiers in Pain Research interstitial cystitis bladder pain syndrome IC/BPS epidemiology prevalence sex/gender |
| title | National prevalence of IC/BPS in women and men utilizing veterans health administration data |
| title_full | National prevalence of IC/BPS in women and men utilizing veterans health administration data |
| title_fullStr | National prevalence of IC/BPS in women and men utilizing veterans health administration data |
| title_full_unstemmed | National prevalence of IC/BPS in women and men utilizing veterans health administration data |
| title_short | National prevalence of IC/BPS in women and men utilizing veterans health administration data |
| title_sort | national prevalence of ic bps in women and men utilizing veterans health administration data |
| topic | interstitial cystitis bladder pain syndrome IC/BPS epidemiology prevalence sex/gender |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2022.925834/full |
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