Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity
The scientific community has reported several cases of microbes that exhibit elevated rates of antibiotic resistance in different regions of the planet. Due to this emergence of antimicrobial resistant microorganisms, the use of antibiotics as promoters of livestock animals’ growth is being banned i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00326/full |
| _version_ | 1818522761313648640 |
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| author | Julio Villena Julio Villena Julio Villena Hisashi Aso Hisashi Aso Victor P. M. G. Rutten Hideki Takahashi Hideki Takahashi Willem van Eden Haruki Kitazawa Haruki Kitazawa |
| author_facet | Julio Villena Julio Villena Julio Villena Hisashi Aso Hisashi Aso Victor P. M. G. Rutten Hideki Takahashi Hideki Takahashi Willem van Eden Haruki Kitazawa Haruki Kitazawa |
| author_sort | Julio Villena |
| collection | DOAJ |
| description | The scientific community has reported several cases of microbes that exhibit elevated rates of antibiotic resistance in different regions of the planet. Due to this emergence of antimicrobial resistant microorganisms, the use of antibiotics as promoters of livestock animals’ growth is being banned in most countries around the world. One of the challenges of agricultural immunology therefore is to find alternatives by modulating the immune system of animals in drug-independent safe food production systems. In this regard, in an effort to supplant antibiotics from bovine feeds, several alternatives were proposed including the use of immunomodulatory probiotics (immunobiotics). The purpose of this review is to provide an update of the status of the modulation of intestinal antiviral innate immunity of the bovine host by immunobiotics, and the beneficial impact of immunobiotics on viral infections, focused on intestinal epithelial cells (IECs). The results of our group, which demonstrate the capacity of immunobiotic strains to beneficially modulate Toll-like receptor 3-triggered immune responses in bovine IECs and improve the resistance to viral infections, are highlighted. This review provides comprehensive information on the innate immune response of bovine IECs against virus, which can be further investigated for the development of strategies aimed to improve defenses in the bovine host. |
| first_indexed | 2024-12-11T05:37:17Z |
| format | Article |
| id | doaj.art-9d51d03b91264688b86f7a30fdbf4692 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T05:37:17Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9d51d03b91264688b86f7a30fdbf46922022-12-22T01:19:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-03-01910.3389/fimmu.2018.00326329633Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral ImmunityJulio Villena0Julio Villena1Julio Villena2Hisashi Aso3Hisashi Aso4Victor P. M. G. Rutten5Hideki Takahashi6Hideki Takahashi7Willem van Eden8Haruki Kitazawa9Haruki Kitazawa10Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, ArgentinaImmunobiotics Research Group, Tucuman, ArgentinaFood and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, JapanCell Biology Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, JapanLivestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai, JapanDepartment of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsLaboratory of Plant Pathology, Graduate School of Agricultural Science, Tohoku University, Sendai, JapanPlant Immunology Unit, International Education and Research Center for Food Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai, JapanDepartment of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsFood and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, JapanLivestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai, JapanThe scientific community has reported several cases of microbes that exhibit elevated rates of antibiotic resistance in different regions of the planet. Due to this emergence of antimicrobial resistant microorganisms, the use of antibiotics as promoters of livestock animals’ growth is being banned in most countries around the world. One of the challenges of agricultural immunology therefore is to find alternatives by modulating the immune system of animals in drug-independent safe food production systems. In this regard, in an effort to supplant antibiotics from bovine feeds, several alternatives were proposed including the use of immunomodulatory probiotics (immunobiotics). The purpose of this review is to provide an update of the status of the modulation of intestinal antiviral innate immunity of the bovine host by immunobiotics, and the beneficial impact of immunobiotics on viral infections, focused on intestinal epithelial cells (IECs). The results of our group, which demonstrate the capacity of immunobiotic strains to beneficially modulate Toll-like receptor 3-triggered immune responses in bovine IECs and improve the resistance to viral infections, are highlighted. This review provides comprehensive information on the innate immune response of bovine IECs against virus, which can be further investigated for the development of strategies aimed to improve defenses in the bovine host.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00326/fullimmunobioticsantiviral immunitybeneficial microbesbovine rotavirustoll-like receptor 3 pathwayinflammation |
| spellingShingle | Julio Villena Julio Villena Julio Villena Hisashi Aso Hisashi Aso Victor P. M. G. Rutten Hideki Takahashi Hideki Takahashi Willem van Eden Haruki Kitazawa Haruki Kitazawa Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity Frontiers in Immunology immunobiotics antiviral immunity beneficial microbes bovine rotavirus toll-like receptor 3 pathway inflammation |
| title | Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity |
| title_full | Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity |
| title_fullStr | Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity |
| title_full_unstemmed | Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity |
| title_short | Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity |
| title_sort | immunobiotics for the bovine host their interaction with intestinal epithelial cells and their effect on antiviral immunity |
| topic | immunobiotics antiviral immunity beneficial microbes bovine rotavirus toll-like receptor 3 pathway inflammation |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00326/full |
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