17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study
The arterial switch operation (ASO) is now days the standard procedure for transposition of the great arteries (d-TGA) repair. Nonetheless, reduced exercise capacity, coronary artery abnormalities, decreased coronary artery vaso-reactivity, reduced coronary flow reserve, proximal intimal proliferati...
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| Format: | Article |
| Language: | English |
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Saudi Heart Association
2015-10-01
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| Series: | Journal of the Saudi Heart Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1016731515002572 |
| _version_ | 1811205965154877440 |
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| author | Giovanni Di Salvo Ziad Al Bulbul Ziad Issa Bahaa Fadel Abdullah Al-Sehly Valeria Pergola Zohair Al Halees Majid Al Fayyadh |
| author_facet | Giovanni Di Salvo Ziad Al Bulbul Ziad Issa Bahaa Fadel Abdullah Al-Sehly Valeria Pergola Zohair Al Halees Majid Al Fayyadh |
| author_sort | Giovanni Di Salvo |
| collection | DOAJ |
| description | The arterial switch operation (ASO) is now days the standard procedure for transposition of the great arteries (d-TGA) repair. Nonetheless, reduced exercise capacity, coronary artery abnormalities, decreased coronary artery vaso-reactivity, reduced coronary flow reserve, proximal intimal proliferation, and reversible myocardial perfusion defects have been demonstrated in ASO patients. Despite of this, indices of systolic function, as assessed by standard echocardiography are within the normal range in ASO patients. Speckle-tracking echocardiography (STE), can detect early subclinical myocardial abnormalities in several diseases even in presence of normal left ventricular (LV) ejection fraction (EF).
to assess LV myocardial deformation and torsion in asymptomatic ASO patients with normal LV EF (⩾55%) by using two-dimensionally derived STE.
Methods: We studied: (a) Sixty-two asymptomatic patients (26 female) who have undergone 1-stage ASO for simple d-TGA, aged 8.5 ± 5.7 years, with a normal LV EF (⩾55%); (b) Thirty-two age and sex comparable controls (14 female), aged 7.9 ± 4.9 years.
Results: In ASO patients, global LV longitudinal strain was significantly lower than in controls (−19.2 ± 2.9% vs −22.7 ± 2.4%, respectively, p < 0.0001). Longitudinal deformation was significantly impaired in the anterior and both anterior and posterior septal walls. In ASO patients global circumferential strain (−23.9 ± 4.8% vs −25.9 ± 4.1%, respectively, p = 0.06) and LV torsion (12.1 ± 4.8° vs 13.1 ± 5.4°, respectively, p = 0.351) were similar to those measured in controls.
Conclusions: To the best of our knowledge this is the largest study on ASO patients by using STE. We demonstrated that in asymptomatic ASO patients despite a normal LV EF (⩾55%) there is a significant reduction in longitudinal myocardial deformation while circumferential deformation and LV torsion are preserved, in order to maintain a normal LV EF. |
| first_indexed | 2024-04-12T03:40:08Z |
| format | Article |
| id | doaj.art-9d578ec0501f43fdaaade19e442244be |
| institution | Directory Open Access Journal |
| issn | 1016-7315 |
| language | English |
| last_indexed | 2024-04-12T03:40:08Z |
| publishDate | 2015-10-01 |
| publisher | Saudi Heart Association |
| record_format | Article |
| series | Journal of the Saudi Heart Association |
| spelling | doaj.art-9d578ec0501f43fdaaade19e442244be2022-12-22T03:49:19ZengSaudi Heart AssociationJournal of the Saudi Heart Association1016-73152015-10-0127430610.1016/j.jsha.2015.05.19817. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography studyGiovanni Di SalvoZiad Al BulbulZiad IssaBahaa FadelAbdullah Al-SehlyValeria PergolaZohair Al HaleesMajid Al FayyadhThe arterial switch operation (ASO) is now days the standard procedure for transposition of the great arteries (d-TGA) repair. Nonetheless, reduced exercise capacity, coronary artery abnormalities, decreased coronary artery vaso-reactivity, reduced coronary flow reserve, proximal intimal proliferation, and reversible myocardial perfusion defects have been demonstrated in ASO patients. Despite of this, indices of systolic function, as assessed by standard echocardiography are within the normal range in ASO patients. Speckle-tracking echocardiography (STE), can detect early subclinical myocardial abnormalities in several diseases even in presence of normal left ventricular (LV) ejection fraction (EF). to assess LV myocardial deformation and torsion in asymptomatic ASO patients with normal LV EF (⩾55%) by using two-dimensionally derived STE. Methods: We studied: (a) Sixty-two asymptomatic patients (26 female) who have undergone 1-stage ASO for simple d-TGA, aged 8.5 ± 5.7 years, with a normal LV EF (⩾55%); (b) Thirty-two age and sex comparable controls (14 female), aged 7.9 ± 4.9 years. Results: In ASO patients, global LV longitudinal strain was significantly lower than in controls (−19.2 ± 2.9% vs −22.7 ± 2.4%, respectively, p < 0.0001). Longitudinal deformation was significantly impaired in the anterior and both anterior and posterior septal walls. In ASO patients global circumferential strain (−23.9 ± 4.8% vs −25.9 ± 4.1%, respectively, p = 0.06) and LV torsion (12.1 ± 4.8° vs 13.1 ± 5.4°, respectively, p = 0.351) were similar to those measured in controls. Conclusions: To the best of our knowledge this is the largest study on ASO patients by using STE. We demonstrated that in asymptomatic ASO patients despite a normal LV EF (⩾55%) there is a significant reduction in longitudinal myocardial deformation while circumferential deformation and LV torsion are preserved, in order to maintain a normal LV EF.http://www.sciencedirect.com/science/article/pii/S1016731515002572 |
| spellingShingle | Giovanni Di Salvo Ziad Al Bulbul Ziad Issa Bahaa Fadel Abdullah Al-Sehly Valeria Pergola Zohair Al Halees Majid Al Fayyadh 17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study Journal of the Saudi Heart Association |
| title | 17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study |
| title_full | 17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study |
| title_fullStr | 17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study |
| title_full_unstemmed | 17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study |
| title_short | 17. Global and regional left ventricular function after arterial switch operation: A speckle tracking echocardiography study |
| title_sort | 17 global and regional left ventricular function after arterial switch operation a speckle tracking echocardiography study |
| url | http://www.sciencedirect.com/science/article/pii/S1016731515002572 |
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