SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA
ABSTRACT Objective: To study the relationship between the serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) in patients with Ewing´s Sarcoma (ES) . Methods: This is a case series with retrospective evaluation of patients with dia...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2016-08-01
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| Series: | Acta Ortopédica Brasileira |
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| Online Access: | http://www.scielo.br/pdf/aob/v24n4/1413-7852-aob-24-04-00196.pdf |
| _version_ | 1818743509058846720 |
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| author | André Mathias Baptista Juan Pablo Zumárraga Renan Pires Negrão dos Santos Guilherme de Oliveira Haubert Olavo Pires de Camargo |
| author_facet | André Mathias Baptista Juan Pablo Zumárraga Renan Pires Negrão dos Santos Guilherme de Oliveira Haubert Olavo Pires de Camargo |
| author_sort | André Mathias Baptista |
| collection | DOAJ |
| description | ABSTRACT Objective: To study the relationship between the serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) in patients with Ewing´s Sarcoma (ES) . Methods: This is a case series with retrospective evaluation of patients with diagnosis of ES divided into 2 groups: Group 1, patients whose serum levels of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were obtained in the staging phase before preoperative chemotherapy (CT), and Group 2, patients whose values were measured after completion of the preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens extracted in surgery was also evaluated . Results: Eighty four medical records from 1995 to 2015 were included. Both AP as LDH decreased in the patients studied, the pre CT value being higher than the post CT value. The average decrease of LHD was 272.95 U/L and AP was 10.17 U/L. The average tumor necrosis was 65.12 %. There was no statistical correlation between serums levels and the tumor necrosis percentage . Conclusion: The serum levels values of AP and LDH are not predictors for chemotherapy-induced necrosis in patients with ES. Level of Evidence IV, Case Series. |
| first_indexed | 2024-12-18T02:29:32Z |
| format | Article |
| id | doaj.art-9d59488a83a84371a1dad0c865467dcc |
| institution | Directory Open Access Journal |
| issn | 1413-7852 |
| language | English |
| last_indexed | 2024-12-18T02:29:32Z |
| publishDate | 2016-08-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Acta Ortopédica Brasileira |
| spelling | doaj.art-9d59488a83a84371a1dad0c865467dcc2022-12-21T21:23:57ZengSociedade Brasileira de Ortopedia e TraumatologiaActa Ortopédica Brasileira1413-78522016-08-0124419619910.1590/1413-785220162404161312SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMAAndré Mathias BaptistaJuan Pablo ZumárragaRenan Pires Negrão dos SantosGuilherme de Oliveira HaubertOlavo Pires de CamargoABSTRACT Objective: To study the relationship between the serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) in patients with Ewing´s Sarcoma (ES) . Methods: This is a case series with retrospective evaluation of patients with diagnosis of ES divided into 2 groups: Group 1, patients whose serum levels of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were obtained in the staging phase before preoperative chemotherapy (CT), and Group 2, patients whose values were measured after completion of the preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens extracted in surgery was also evaluated . Results: Eighty four medical records from 1995 to 2015 were included. Both AP as LDH decreased in the patients studied, the pre CT value being higher than the post CT value. The average decrease of LHD was 272.95 U/L and AP was 10.17 U/L. The average tumor necrosis was 65.12 %. There was no statistical correlation between serums levels and the tumor necrosis percentage . Conclusion: The serum levels values of AP and LDH are not predictors for chemotherapy-induced necrosis in patients with ES. Level of Evidence IV, Case Series.http://www.scielo.br/pdf/aob/v24n4/1413-7852-aob-24-04-00196.pdfSarcomaEwing. Alkaline phosphatase. L-Lactate dehydrogenase. Tumor necrosis factor-alpha. Drug therapy. Prognosis. |
| spellingShingle | André Mathias Baptista Juan Pablo Zumárraga Renan Pires Negrão dos Santos Guilherme de Oliveira Haubert Olavo Pires de Camargo SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA Acta Ortopédica Brasileira Sarcoma Ewing. Alkaline phosphatase. L-Lactate dehydrogenase. Tumor necrosis factor-alpha. Drug therapy. Prognosis. |
| title | SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA |
| title_full | SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA |
| title_fullStr | SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA |
| title_full_unstemmed | SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA |
| title_short | SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA |
| title_sort | serum values of alkaline phosphatase and lactate dehydrogenase in ewing s sarcoma |
| topic | Sarcoma Ewing. Alkaline phosphatase. L-Lactate dehydrogenase. Tumor necrosis factor-alpha. Drug therapy. Prognosis. |
| url | http://www.scielo.br/pdf/aob/v24n4/1413-7852-aob-24-04-00196.pdf |
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