Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs
The misuse of psychoactive substances is attracting a great deal of attention from the general public. An increase use of psychoactive substances is observed among young people who do not have enough awareness of the harmful effects of these substances. Easy access to illicit drugs at low cost and l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-02-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2021-0196 |
| _version_ | 1818509970196398080 |
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| author | Lukić Vera Micić Ružica Arsić Biljana Nedović Bojan Radosavljević Živana |
| author_facet | Lukić Vera Micić Ružica Arsić Biljana Nedović Bojan Radosavljević Živana |
| author_sort | Lukić Vera |
| collection | DOAJ |
| description | The misuse of psychoactive substances is attracting a great deal of attention from the general public. An increase use of psychoactive substances is observed among young people who do not have enough awareness of the harmful effects of these substances. Easy access to illicit drugs at low cost and lack of effective means of routine screening for new psychoactive substances (NPS) have contributed to the rapid increase in their use. New research and evidence suggest that drug use can cause a variety of adverse psychological and physiological effects on human health (anxiety, panic, paranoia, psychosis, and seizures). We describe different classes of these NPS drugs with emphasis on the methods used to identify them and the identification of their metabolites in biological specimens. This is the first review that thoroughly gives the literature on both natural and synthetic illegal drugs with old known data and very hot new topics and investigations, which enables the researcher to use it as a starting point in the literature exploration and planning of the own research. For the first time, the conformational analysis was done for selected illegal drugs, giving rise to the search of the biologically active conformations both theoretically and using lab experiments. |
| first_indexed | 2024-12-10T22:52:46Z |
| format | Article |
| id | doaj.art-9d5972e7b0d84226ae3bb924f84ffe0c |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-12-10T22:52:46Z |
| publishDate | 2021-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-9d5972e7b0d84226ae3bb924f84ffe0c2022-12-22T01:30:22ZengDe GruyterOpen Chemistry2391-54202021-02-011916010610.1515/chem-2021-0196Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugsLukić Vera0Micić Ružica1Arsić Biljana2Nedović Bojan3Radosavljević Živana4Institute of Forensic Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Republic of SerbiaDepartment of Chemistry, Faculty of Sciences and Mathematics, University of Priština, Kosovska Mitrovica, Republic of SerbiaDepartment of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Niš, Republic of SerbiaFaculty of Medicine, University of Niš, Niš, Republic of SerbiaDepartment of Chemistry, Faculty of Sciences and Mathematics, University of Priština, Kosovska Mitrovica, Republic of SerbiaThe misuse of psychoactive substances is attracting a great deal of attention from the general public. An increase use of psychoactive substances is observed among young people who do not have enough awareness of the harmful effects of these substances. Easy access to illicit drugs at low cost and lack of effective means of routine screening for new psychoactive substances (NPS) have contributed to the rapid increase in their use. New research and evidence suggest that drug use can cause a variety of adverse psychological and physiological effects on human health (anxiety, panic, paranoia, psychosis, and seizures). We describe different classes of these NPS drugs with emphasis on the methods used to identify them and the identification of their metabolites in biological specimens. This is the first review that thoroughly gives the literature on both natural and synthetic illegal drugs with old known data and very hot new topics and investigations, which enables the researcher to use it as a starting point in the literature exploration and planning of the own research. For the first time, the conformational analysis was done for selected illegal drugs, giving rise to the search of the biologically active conformations both theoretically and using lab experiments.https://doi.org/10.1515/chem-2021-0196illegal drugscathinonesphenethylaminescannabinoidstryptamines |
| spellingShingle | Lukić Vera Micić Ružica Arsić Biljana Nedović Bojan Radosavljević Živana Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs Open Chemistry illegal drugs cathinones phenethylamines cannabinoids tryptamines |
| title | Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs |
| title_full | Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs |
| title_fullStr | Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs |
| title_full_unstemmed | Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs |
| title_short | Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs |
| title_sort | overview of the major classes of new psychoactive substances psychoactive effects analytical determination and conformational analysis of selected illegal drugs |
| topic | illegal drugs cathinones phenethylamines cannabinoids tryptamines |
| url | https://doi.org/10.1515/chem-2021-0196 |
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