Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms
Cerebral venous outflow disturbance (CVOD) has begun to garner the attention of researches owing to a series of clinical symptoms that impose a significant impact on people's quality of life. Herein, we aimed to investigate whether normobaric oxygen (NBO) can ameliorate CVOD-induced neurologica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.599985/full |
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| author | Jiayue Ding Jiayue Ding Yu Liu Xiangyu Li Zhiying Chen Zhiying Chen Zhiying Chen Jingwei Guan Jingwei Guan Jingwei Guan Kexin Jin Kexin Jin Kexin Jin Zhongao Wang Zhongao Wang Zhongao Wang Yuchuan Ding Yuchuan Ding Xunming Ji Xunming Ji Xunming Ji Ran Meng Ran Meng Ran Meng |
| author_facet | Jiayue Ding Jiayue Ding Yu Liu Xiangyu Li Zhiying Chen Zhiying Chen Zhiying Chen Jingwei Guan Jingwei Guan Jingwei Guan Kexin Jin Kexin Jin Kexin Jin Zhongao Wang Zhongao Wang Zhongao Wang Yuchuan Ding Yuchuan Ding Xunming Ji Xunming Ji Xunming Ji Ran Meng Ran Meng Ran Meng |
| author_sort | Jiayue Ding |
| collection | DOAJ |
| description | Cerebral venous outflow disturbance (CVOD) has begun to garner the attention of researches owing to a series of clinical symptoms that impose a significant impact on people's quality of life. Herein, we aimed to investigate whether normobaric oxygen (NBO) can ameliorate CVOD-induced neurological symptoms. This was one part of the prospective trial registered in ClinicalTrials.gov (NCT03373292). A total of 37 CVOD patients were divided into the NBO group (5–8 L/min of oxygen inhalation, 1 h per time, 3 times daily, n = 19) and the control group (without oxygen inhalation, n = 18) randomly. The assessments were performed at admission, 1-week hospitalization, and 6-month follow-up. Quantitative electroencephalogram (qEEG) data were recorded prior to and post 1 h of NBO in some patients. R software was used for data analysis. No NBO-related adverse events were observed during the whole NBO intervention process. The 1-week Patient Global Impression of Change (PGIC) scale showed that the symptom improvement occurred in nine patients in the NBO group (47.4%) while none in the control group (p = 0.001). NBO could improve headache evaluated with visual analog scale (pre-NBO vs. post-NBO: 4.70 ± 2.16 vs. 2.90 ± 2.03, p = 0.024) and Headache Impact Test-6 (53.40 ± 12.15 vs. 50.30 ± 13.04, p = 0.041). As for 6-month PGIC follow-up, eight out of 14 cases (57.1%) in the NBO group reported improvement, while only one out of 12 patients in the control group replied mild improvement (p = 0.014). The qEEG revealed that NBO reduced the ratio of theta to alpha power (0.65 ± 0.38 vs. 0.56 ± 0.35, p = 0.030) over the fronto-central electrodes. To sum up, NBO may be a safe and effective approach to attenuate CVOD-related symptoms (especially for headache) by brain functional improvement resulting from increasing oxygen supply to the brain tissues. |
| first_indexed | 2024-12-23T05:14:54Z |
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| id | doaj.art-9d5ad1fc8f83484096a553fa8f7de0af |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-23T05:14:54Z |
| publishDate | 2020-11-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-9d5ad1fc8f83484096a553fa8f7de0af2022-12-21T17:58:52ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-11-011110.3389/fneur.2020.599985599985Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological SymptomsJiayue Ding0Jiayue Ding1Yu Liu2Xiangyu Li3Zhiying Chen4Zhiying Chen5Zhiying Chen6Jingwei Guan7Jingwei Guan8Jingwei Guan9Kexin Jin10Kexin Jin11Kexin Jin12Zhongao Wang13Zhongao Wang14Zhongao Wang15Yuchuan Ding16Yuchuan Ding17Xunming Ji18Xunming Ji19Xunming Ji20Ran Meng21Ran Meng22Ran Meng23Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Tianjin Medical University General Hospital, Tianjin, ChinaEpilepsy Center, Beijing Fengtai You'anmen Hospital, Beijing, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaAdvanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaAdvanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaAdvanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaAdvanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United StatesAdvanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaAdvanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaDepartment of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, ChinaCerebral venous outflow disturbance (CVOD) has begun to garner the attention of researches owing to a series of clinical symptoms that impose a significant impact on people's quality of life. Herein, we aimed to investigate whether normobaric oxygen (NBO) can ameliorate CVOD-induced neurological symptoms. This was one part of the prospective trial registered in ClinicalTrials.gov (NCT03373292). A total of 37 CVOD patients were divided into the NBO group (5–8 L/min of oxygen inhalation, 1 h per time, 3 times daily, n = 19) and the control group (without oxygen inhalation, n = 18) randomly. The assessments were performed at admission, 1-week hospitalization, and 6-month follow-up. Quantitative electroencephalogram (qEEG) data were recorded prior to and post 1 h of NBO in some patients. R software was used for data analysis. No NBO-related adverse events were observed during the whole NBO intervention process. The 1-week Patient Global Impression of Change (PGIC) scale showed that the symptom improvement occurred in nine patients in the NBO group (47.4%) while none in the control group (p = 0.001). NBO could improve headache evaluated with visual analog scale (pre-NBO vs. post-NBO: 4.70 ± 2.16 vs. 2.90 ± 2.03, p = 0.024) and Headache Impact Test-6 (53.40 ± 12.15 vs. 50.30 ± 13.04, p = 0.041). As for 6-month PGIC follow-up, eight out of 14 cases (57.1%) in the NBO group reported improvement, while only one out of 12 patients in the control group replied mild improvement (p = 0.014). The qEEG revealed that NBO reduced the ratio of theta to alpha power (0.65 ± 0.38 vs. 0.56 ± 0.35, p = 0.030) over the fronto-central electrodes. To sum up, NBO may be a safe and effective approach to attenuate CVOD-related symptoms (especially for headache) by brain functional improvement resulting from increasing oxygen supply to the brain tissues.https://www.frontiersin.org/articles/10.3389/fneur.2020.599985/fullnormobaric oxygencerebral venous outflow disturbancebrain dysfunctionEEGneurological impairment |
| spellingShingle | Jiayue Ding Jiayue Ding Yu Liu Xiangyu Li Zhiying Chen Zhiying Chen Zhiying Chen Jingwei Guan Jingwei Guan Jingwei Guan Kexin Jin Kexin Jin Kexin Jin Zhongao Wang Zhongao Wang Zhongao Wang Yuchuan Ding Yuchuan Ding Xunming Ji Xunming Ji Xunming Ji Ran Meng Ran Meng Ran Meng Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms Frontiers in Neurology normobaric oxygen cerebral venous outflow disturbance brain dysfunction EEG neurological impairment |
| title | Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms |
| title_full | Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms |
| title_fullStr | Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms |
| title_full_unstemmed | Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms |
| title_short | Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms |
| title_sort | normobaric oxygen may ameliorate cerebral venous outflow disturbance related neurological symptoms |
| topic | normobaric oxygen cerebral venous outflow disturbance brain dysfunction EEG neurological impairment |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.599985/full |
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