Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
Cells delay completion of cytokinesis when chromatin is trapped at the intercellular bridge. Here, Petsalaki and Zachos report that Cdc-like kinases (Clks) 1, 2 and 4 localize to the midbody and phosphorylate the mitotic kinase Aurora B, imposing the abscission checkpoint to prevent premature abscis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11451 |