Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy
Revascularization of both left main and bifurcation lesions is currently considered an important feature of complex percutaneous coronary intervention (PCI), whereas stenting distal left main bifurcation is fairly challenging. Recent evidence shows that such lesions are associated with an increased...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-06-01
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| Series: | US Cardiology Review |
| Online Access: | https://uscjournal.com/articleindex/usc.2020.34 |
| _version_ | 1797200063226707968 |
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| author | Charalampos Varlamos Ioannis Lianos Despoina-Rafailia Benetou Dimitrios Alexopoulos |
| author_facet | Charalampos Varlamos Ioannis Lianos Despoina-Rafailia Benetou Dimitrios Alexopoulos |
| author_sort | Charalampos Varlamos |
| collection | DOAJ |
| description | Revascularization of both left main and bifurcation lesions is currently considered an important feature of complex percutaneous coronary intervention (PCI), whereas stenting distal left main bifurcation is fairly challenging. Recent evidence shows that such lesions are associated with an increased risk of ischemic events. There is no universal consensus on the optimal PCI strategy or the appropriate type and duration of antithrombotic therapy to mitigate the thrombotic risk. Prolonged dual antiplatelet therapy or use of more potent P2Y12 inhibitors have been investigated in the context of this high-risk subset of the population undergoing PCI. Thus, while complex PCI is a growing field in interventional cardiology, left main and bifurcation PCI constitutes a fair amount of the total complex procedures performed recently, and there is cumulative interest regarding antithrombotic therapy type and duration in this subset of patients, with decision-making mostly based on clinical presentation, baseline bleeding, and ischemic risk, as well as the performed stenting strategy. |
| first_indexed | 2024-03-07T17:41:11Z |
| format | Article |
| id | doaj.art-9d5b5473bb8c423f83308d30bd397e07 |
| institution | Directory Open Access Journal |
| issn | 1758-3896 1758-390X |
| language | English |
| last_indexed | 2024-04-24T07:25:41Z |
| publishDate | 2021-06-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj.art-9d5b5473bb8c423f83308d30bd397e072024-04-20T16:02:16ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2021-06-011510.15420/usc.2020.34Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic TherapyCharalampos Varlamos0Ioannis Lianos1Despoina-Rafailia Benetou2Dimitrios Alexopoulos3Second Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, GreeceSecond Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, GreeceSecond Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, GreeceSecond Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, GreeceRevascularization of both left main and bifurcation lesions is currently considered an important feature of complex percutaneous coronary intervention (PCI), whereas stenting distal left main bifurcation is fairly challenging. Recent evidence shows that such lesions are associated with an increased risk of ischemic events. There is no universal consensus on the optimal PCI strategy or the appropriate type and duration of antithrombotic therapy to mitigate the thrombotic risk. Prolonged dual antiplatelet therapy or use of more potent P2Y12 inhibitors have been investigated in the context of this high-risk subset of the population undergoing PCI. Thus, while complex PCI is a growing field in interventional cardiology, left main and bifurcation PCI constitutes a fair amount of the total complex procedures performed recently, and there is cumulative interest regarding antithrombotic therapy type and duration in this subset of patients, with decision-making mostly based on clinical presentation, baseline bleeding, and ischemic risk, as well as the performed stenting strategy.https://uscjournal.com/articleindex/usc.2020.34 |
| spellingShingle | Charalampos Varlamos Ioannis Lianos Despoina-Rafailia Benetou Dimitrios Alexopoulos Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy US Cardiology Review |
| title | Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy |
| title_full | Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy |
| title_fullStr | Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy |
| title_full_unstemmed | Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy |
| title_short | Left Main Disease and Bifurcation Percutaneous Coronary Intervention: Focus on Antithrombotic Therapy |
| title_sort | left main disease and bifurcation percutaneous coronary intervention focus on antithrombotic therapy |
| url | https://uscjournal.com/articleindex/usc.2020.34 |
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