Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces
Abstract Purpose Osseointegration consists of bidirectional bone formation around modified implant surfaces by contact osteogenesis and distance osteogenesis. This study tested whether contact osteogenesis on the surface of a modified titanium (Ti) implant is stimulated by cytokines in the blood. Me...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | International Journal of Implant Dentistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40729-022-00427-1 |
| _version_ | 1818207398146342912 |
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| author | Ung-Gyu Kim Jung-You Choi Jun-Beom Lee In-Sung Luke Yeo |
| author_facet | Ung-Gyu Kim Jung-You Choi Jun-Beom Lee In-Sung Luke Yeo |
| author_sort | Ung-Gyu Kim |
| collection | DOAJ |
| description | Abstract Purpose Osseointegration consists of bidirectional bone formation around modified implant surfaces by contact osteogenesis and distance osteogenesis. This study tested whether contact osteogenesis on the surface of a modified titanium (Ti) implant is stimulated by cytokines in the blood. Methods In the first two types of experiments, sandblasted, large-grit, acid-etched Ti implants and turned Ti tubes were inserted into rabbit tibiae. To exclude the influence of distance osteogenesis, the tubes were inserted into the tibiae, and implants were placed inside the tubes. In a third type of experiment, the implants and tubes were inserted into the rabbit tibiae, and platelet-rich plasma (PRP) or recombinant human bone morphogenetic protein-2 (rhBMP-2) was applied topically. Four weeks after implantation, undecalcified specimens were prepared for histomorphometry. Bone-to-implant contact (BIC) and bone area per tissue (BA) were measured, and the data were analysed using one-way ANOVA at a significance level of 0.05. Results When the response of bone to Ti tubes with implants was compared to that without implants (first experiment), little bone formation was found inside the tubes. The mean BIC of implant specimens inside the tubes was 21.41 ± 13.81% in a second experiment that evaluated bone responses to implants with or without Ti tubes. This mean BIC value was significantly lower than that in the implant-only group (without tubes) (47.32 ± 12.09%, P = 0.030). The third experiment showed that rhBMP-2 significantly increased contact osteogenesis on the implant surface, whereas PRP had no effect (mean BIC: 66.53 ± 14.06% vs. 16.34 ± 15.98%, P = 0.004). Conclusions Platelet-rich plasma alone is unable to trigger contact osteogenesis on the modified titanium implant surface. |
| first_indexed | 2024-12-12T04:28:17Z |
| format | Article |
| id | doaj.art-9d5d364a7896413993a34f4511a2c516 |
| institution | Directory Open Access Journal |
| issn | 2198-4034 |
| language | English |
| last_indexed | 2024-12-12T04:28:17Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Implant Dentistry |
| spelling | doaj.art-9d5d364a7896413993a34f4511a2c5162022-12-22T00:38:09ZengSpringerOpenInternational Journal of Implant Dentistry2198-40342022-06-018111310.1186/s40729-022-00427-1Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfacesUng-Gyu Kim0Jung-You Choi1Jun-Beom Lee2In-Sung Luke Yeo3Department of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National UniversityDental Research Institute, Seoul National UniversityDepartment of Periodontology, Seoul National University School of DentistryDepartment of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National UniversityAbstract Purpose Osseointegration consists of bidirectional bone formation around modified implant surfaces by contact osteogenesis and distance osteogenesis. This study tested whether contact osteogenesis on the surface of a modified titanium (Ti) implant is stimulated by cytokines in the blood. Methods In the first two types of experiments, sandblasted, large-grit, acid-etched Ti implants and turned Ti tubes were inserted into rabbit tibiae. To exclude the influence of distance osteogenesis, the tubes were inserted into the tibiae, and implants were placed inside the tubes. In a third type of experiment, the implants and tubes were inserted into the rabbit tibiae, and platelet-rich plasma (PRP) or recombinant human bone morphogenetic protein-2 (rhBMP-2) was applied topically. Four weeks after implantation, undecalcified specimens were prepared for histomorphometry. Bone-to-implant contact (BIC) and bone area per tissue (BA) were measured, and the data were analysed using one-way ANOVA at a significance level of 0.05. Results When the response of bone to Ti tubes with implants was compared to that without implants (first experiment), little bone formation was found inside the tubes. The mean BIC of implant specimens inside the tubes was 21.41 ± 13.81% in a second experiment that evaluated bone responses to implants with or without Ti tubes. This mean BIC value was significantly lower than that in the implant-only group (without tubes) (47.32 ± 12.09%, P = 0.030). The third experiment showed that rhBMP-2 significantly increased contact osteogenesis on the implant surface, whereas PRP had no effect (mean BIC: 66.53 ± 14.06% vs. 16.34 ± 15.98%, P = 0.004). Conclusions Platelet-rich plasma alone is unable to trigger contact osteogenesis on the modified titanium implant surface.https://doi.org/10.1186/s40729-022-00427-1Dental implantsOsseointegrationBone morphogenetic proteinsPlatelet-rich plasma |
| spellingShingle | Ung-Gyu Kim Jung-You Choi Jun-Beom Lee In-Sung Luke Yeo Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces International Journal of Implant Dentistry Dental implants Osseointegration Bone morphogenetic proteins Platelet-rich plasma |
| title | Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces |
| title_full | Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces |
| title_fullStr | Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces |
| title_full_unstemmed | Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces |
| title_short | Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces |
| title_sort | platelet rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces |
| topic | Dental implants Osseointegration Bone morphogenetic proteins Platelet-rich plasma |
| url | https://doi.org/10.1186/s40729-022-00427-1 |
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