Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation
Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00987/full |
| _version_ | 1818038658213609472 |
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| author | Franz Felix Konen Philipp Schwenkenbecher Konstantin Fritz Jendretzky Martin Werner Hümmert Florian Wegner Martin Stangel Kurt-Wolfram Sühs Thomas Skripuletz |
| author_facet | Franz Felix Konen Philipp Schwenkenbecher Konstantin Fritz Jendretzky Martin Werner Hümmert Florian Wegner Martin Stangel Kurt-Wolfram Sühs Thomas Skripuletz |
| author_sort | Franz Felix Konen |
| collection | DOAJ |
| description | Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy following liver transplantation. Although a broad spectrum of different immunotherapies was applied and anti-NMDA receptor antibody titers gradually decreased, the clinical course could not be affected positively. Autoimmune encephalitis after transplantation is only described in a few cases and not well-recognized. Our case adds further evidence for anti-NMDA receptor encephalitis as the cause of neuropsychiatric symptoms even under immunosuppressive therapy in a post-transplant setting. |
| first_indexed | 2024-12-10T07:46:14Z |
| format | Article |
| id | doaj.art-9d5eab112f4d4a7f979e2dc72d3138a1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T07:46:14Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-9d5eab112f4d4a7f979e2dc72d3138a12022-12-22T01:57:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-09-011010.3389/fneur.2019.00987484581Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver TransplantationFranz Felix KonenPhilipp SchwenkenbecherKonstantin Fritz JendretzkyMartin Werner HümmertFlorian WegnerMartin StangelKurt-Wolfram SühsThomas SkripuletzAnti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy following liver transplantation. Although a broad spectrum of different immunotherapies was applied and anti-NMDA receptor antibody titers gradually decreased, the clinical course could not be affected positively. Autoimmune encephalitis after transplantation is only described in a few cases and not well-recognized. Our case adds further evidence for anti-NMDA receptor encephalitis as the cause of neuropsychiatric symptoms even under immunosuppressive therapy in a post-transplant setting.https://www.frontiersin.org/article/10.3389/fneur.2019.00987/fullEpstein-Barr virusanti-NMDA receptor encephalitisimmunosuppressionliver-transplantationautoimmune encephalitis |
| spellingShingle | Franz Felix Konen Philipp Schwenkenbecher Konstantin Fritz Jendretzky Martin Werner Hümmert Florian Wegner Martin Stangel Kurt-Wolfram Sühs Thomas Skripuletz Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation Frontiers in Neurology Epstein-Barr virus anti-NMDA receptor encephalitis immunosuppression liver-transplantation autoimmune encephalitis |
| title | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
| title_full | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
| title_fullStr | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
| title_full_unstemmed | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
| title_short | Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation |
| title_sort | severe anti n methyl d aspartate receptor encephalitis under immunosuppression after liver transplantation |
| topic | Epstein-Barr virus anti-NMDA receptor encephalitis immunosuppression liver-transplantation autoimmune encephalitis |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00987/full |
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