Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset
Intracranial aneurysm (IA) rupture is a common cause of hemorrhagic stroke. The treatment of unruptured IAs is a challenging decision that requires delicate risk stratification. The rate of poor clinical outcomes after surgical intervention (aneurysm clipping) or endovascular coiling remains elevate...
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| Format: | Article |
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Elsevier
2024-02-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340923010417 |
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| author | Mannekomba R. Diagbouga Sylvain Lemeille Sandrine Morel Brenda R. Kwak |
| author_facet | Mannekomba R. Diagbouga Sylvain Lemeille Sandrine Morel Brenda R. Kwak |
| author_sort | Mannekomba R. Diagbouga |
| collection | DOAJ |
| description | Intracranial aneurysm (IA) rupture is a common cause of hemorrhagic stroke. The treatment of unruptured IAs is a challenging decision that requires delicate risk stratification. The rate of poor clinical outcomes after surgical intervention (aneurysm clipping) or endovascular coiling remains elevated (6.7% and 4.8%, respectively), and they do not provide an absolute guarantee to prevent IA growth and rupture. Currently, there is no pharmaceutical treatment to cure or stabilize IAs. Improving the current or developing new treatments for IA disease would require a better understanding of the cellular and molecular mechanisms occurring in the different stages of the disease.Hemodynamic forces play a critical role in IA disease. While the role of wall shear stress in IAs is well-established, the influence of cyclic circumferential stretch (CCS) still needs clarification. IAs are generally characterized by a lack of CCS. In this investigation, we sought to understand the effect of aneurysmal CCS on endothelial cell (EC) function and its potential significance in IA disease, hypothesizing that CCS can influence IA wall remodelling. RNA-seq data were generated from human umbilical vein ECs (HUVECs) exposed to physiological (6%) or aneurysmal CCS (static). We performed differential gene expression and pathway enrichment analysis. Additionally, we highlighted cell junction gene expression between static and 6% CCS to contribute to the debate about how cell junctions affect endothelium stability and integrity. Researchers in the vascular biology field may benefit from this transcriptomic profile to understand the effect of mechanical stretch on EC biology and its potential significance in vascular disease development. |
| first_indexed | 2024-03-08T03:30:30Z |
| format | Article |
| id | doaj.art-9d5f0b4064e447d18921684ed70648cd |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-03-08T03:30:30Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-9d5f0b4064e447d18921684ed70648cd2024-02-11T05:10:58ZengElsevierData in Brief2352-34092024-02-0152110014Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic datasetMannekomba R. Diagbouga0Sylvain Lemeille1Sandrine Morel2Brenda R. Kwak3Department of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland; Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland; Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland; Division of Neurosurgery, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals and University of Geneva. Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, SwitzerlandDepartment of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland; Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland; Corresponding author.Intracranial aneurysm (IA) rupture is a common cause of hemorrhagic stroke. The treatment of unruptured IAs is a challenging decision that requires delicate risk stratification. The rate of poor clinical outcomes after surgical intervention (aneurysm clipping) or endovascular coiling remains elevated (6.7% and 4.8%, respectively), and they do not provide an absolute guarantee to prevent IA growth and rupture. Currently, there is no pharmaceutical treatment to cure or stabilize IAs. Improving the current or developing new treatments for IA disease would require a better understanding of the cellular and molecular mechanisms occurring in the different stages of the disease.Hemodynamic forces play a critical role in IA disease. While the role of wall shear stress in IAs is well-established, the influence of cyclic circumferential stretch (CCS) still needs clarification. IAs are generally characterized by a lack of CCS. In this investigation, we sought to understand the effect of aneurysmal CCS on endothelial cell (EC) function and its potential significance in IA disease, hypothesizing that CCS can influence IA wall remodelling. RNA-seq data were generated from human umbilical vein ECs (HUVECs) exposed to physiological (6%) or aneurysmal CCS (static). We performed differential gene expression and pathway enrichment analysis. Additionally, we highlighted cell junction gene expression between static and 6% CCS to contribute to the debate about how cell junctions affect endothelium stability and integrity. Researchers in the vascular biology field may benefit from this transcriptomic profile to understand the effect of mechanical stretch on EC biology and its potential significance in vascular disease development.http://www.sciencedirect.com/science/article/pii/S2352340923010417Cyclic mechanical strainEndotheliumRNA-seqCell junctions |
| spellingShingle | Mannekomba R. Diagbouga Sylvain Lemeille Sandrine Morel Brenda R. Kwak Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset Data in Brief Cyclic mechanical strain Endothelium RNA-seq Cell junctions |
| title | Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset |
| title_full | Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset |
| title_fullStr | Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset |
| title_full_unstemmed | Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset |
| title_short | Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset |
| title_sort | impact of disrupted cyclic stretch in intracranial aneurysms insights from endothelial cell transcriptomic dataset |
| topic | Cyclic mechanical strain Endothelium RNA-seq Cell junctions |
| url | http://www.sciencedirect.com/science/article/pii/S2352340923010417 |
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